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Atomistry » Chlorine » PDB 4gm6-4gt9 » 4gmy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4gm6-4gt9 » 4gmy » |
Chlorine in PDB 4gmy: JAK2 Kinase (JH1 Domain) in Complex with 2,6-Dichloro-N-{2- [(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}BenzamideEnzymatic activity of JAK2 Kinase (JH1 Domain) in Complex with 2,6-Dichloro-N-{2- [(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
All present enzymatic activity of JAK2 Kinase (JH1 Domain) in Complex with 2,6-Dichloro-N-{2- [(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide:
2.7.10.2; Protein crystallography data
The structure of JAK2 Kinase (JH1 Domain) in Complex with 2,6-Dichloro-N-{2- [(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide, PDB code: 4gmy
was solved by
J.M.Murray,
S.Shia,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the JAK2 Kinase (JH1 Domain) in Complex with 2,6-Dichloro-N-{2- [(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
(pdb code 4gmy). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the JAK2 Kinase (JH1 Domain) in Complex with 2,6-Dichloro-N-{2- [(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide, PDB code: 4gmy: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4gmyGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the JAK2 Kinase (JH1 Domain) in Complex with 2,6-Dichloro-N-{2- [(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 4gmyGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the JAK2 Kinase (JH1 Domain) in Complex with 2,6-Dichloro-N-{2- [(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
![]() Mono view ![]() Stereo pair view
Reference:
J.Liang,
V.Tsui,
A.Van Abbema,
L.Bao,
K.Barrett,
M.Beresini,
L.Berezhkovskiy,
W.S.Blair,
C.Chang,
J.Driscoll,
C.Eigenbrot,
N.Ghilardi,
P.Gibbons,
J.Halladay,
A.Johnson,
P.B.Kohli,
Y.Lai,
M.Liimatta,
P.Mantik,
K.Menghrajani,
J.Murray,
A.Sambrone,
Y.Xiao,
S.Shia,
Y.Shin,
J.Smith,
S.Sohn,
M.Stanley,
M.Ultsch,
B.Zhang,
L.C.Wu,
S.Magnuson.
Lead Identification of Novel and Selective TYK2 Inhibitors. Eur.J.Med.Chem. V. 67 175 2013.
Page generated: Fri Jul 11 15:46:09 2025
ISSN: ISSN 0223-5234 PubMed: 23867602 DOI: 10.1016/J.EJMECH.2013.03.070 |
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