Atomistry » Chlorine » PDB 4gta-4h1t » 4gum
Atomistry »
  Chlorine »
    PDB 4gta-4h1t »
      4gum »

Chlorine in PDB 4gum: Cystal Structure of Locked-Trimer of Human Mif

Enzymatic activity of Cystal Structure of Locked-Trimer of Human Mif

All present enzymatic activity of Cystal Structure of Locked-Trimer of Human Mif:
5.3.2.1; 5.3.3.12;

Protein crystallography data

The structure of Cystal Structure of Locked-Trimer of Human Mif, PDB code: 4gum was solved by C.Fan, E.Lolis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.79 / 2.33
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 50.315, 100.381, 199.480, 90.00, 90.00, 90.00
R / Rfree (%) 22.2 / 27.2

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Cystal Structure of Locked-Trimer of Human Mif (pdb code 4gum). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Cystal Structure of Locked-Trimer of Human Mif, PDB code: 4gum:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in 4gum

Go back to Chlorine Binding Sites List in 4gum
Chlorine binding site 1 out of 8 in the Cystal Structure of Locked-Trimer of Human Mif


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cystal Structure of Locked-Trimer of Human Mif within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl201

b:66.5
occ:1.00
NZ A:LYS77 3.5 60.9 1.0
CB A:SER74 3.9 48.3 1.0
CD A:LYS77 4.0 51.6 1.0
CE A:LYS77 4.1 58.7 1.0
CA A:SER74 4.2 42.7 1.0
NE A:ARG73 4.4 48.3 1.0
N A:SER74 4.5 36.9 1.0
CG A:ARG73 5.0 37.9 1.0
NH2 A:ARG73 5.0 53.7 1.0

Chlorine binding site 2 out of 8 in 4gum

Go back to Chlorine Binding Sites List in 4gum
Chlorine binding site 2 out of 8 in the Cystal Structure of Locked-Trimer of Human Mif


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cystal Structure of Locked-Trimer of Human Mif within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl201

b:85.3
occ:1.00
N C:GLY17 3.2 50.1 1.0
CA C:GLY17 3.5 49.7 1.0
CB C:LEU19 3.8 42.9 1.0
N C:LEU19 3.9 48.4 1.0
C C:GLY17 3.9 49.4 1.0
OD1 C:ASP16 4.0 70.8 1.0
N C:PHE18 4.1 53.4 1.0
OG B:SER53 4.2 83.6 1.0
CG C:LEU19 4.2 47.0 1.0
OG C:SER20 4.3 68.0 1.0
CB H:ALA70 4.3 87.9 1.0
N C:SER20 4.4 39.9 1.0
CD1 C:LEU19 4.4 37.5 1.0
CA C:LEU19 4.4 41.0 1.0
C C:ASP16 4.5 57.5 1.0
O C:GLY17 4.7 48.5 1.0
CA C:ASP16 4.9 62.8 1.0
C C:LEU19 4.9 47.0 1.0
C C:PHE18 5.0 45.8 1.0

Chlorine binding site 3 out of 8 in 4gum

Go back to Chlorine Binding Sites List in 4gum
Chlorine binding site 3 out of 8 in the Cystal Structure of Locked-Trimer of Human Mif


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cystal Structure of Locked-Trimer of Human Mif within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl202

b:61.5
occ:1.00
NH1 C:ARG73 3.4 86.7 1.0
CA F:GLY17 3.4 47.5 1.0
N F:GLY17 3.5 51.8 1.0
CB F:LEU19 3.6 35.1 1.0
CG F:LEU19 3.7 51.9 1.0
N F:LEU19 3.7 48.0 1.0
C F:GLY17 3.7 48.3 1.0
CD1 F:LEU19 3.8 56.0 1.0
N F:PHE18 3.9 46.2 1.0
OG E:SER53 4.1 78.6 1.0
N F:SER20 4.1 45.7 1.0
CA F:LEU19 4.2 41.9 1.0
OG F:SER20 4.2 49.4 1.0
O F:GLY17 4.4 53.3 1.0
CZ C:ARG73 4.4 78.2 1.0
NH2 C:ARG73 4.6 75.7 1.0
C F:LEU19 4.7 42.8 1.0
C F:PHE18 4.7 48.8 1.0
OD1 F:ASP16 4.8 90.9 1.0
C F:ASP16 4.8 52.9 1.0
CA F:PHE18 4.8 51.3 1.0
CB F:SER20 4.9 51.5 1.0

Chlorine binding site 4 out of 8 in 4gum

Go back to Chlorine Binding Sites List in 4gum
Chlorine binding site 4 out of 8 in the Cystal Structure of Locked-Trimer of Human Mif


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cystal Structure of Locked-Trimer of Human Mif within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl201

b:55.0
occ:1.00
N D:GLY17 3.4 44.3 1.0
CA D:GLY17 3.5 30.9 1.0
CB D:LEU19 3.6 39.4 1.0
N D:LEU19 3.7 40.0 1.0
C D:GLY17 3.8 29.8 1.0
N D:SER20 4.0 36.1 1.0
N D:PHE18 4.0 34.4 1.0
OG D:SER20 4.0 45.0 1.0
CG D:LEU19 4.1 45.5 1.0
CA D:LEU19 4.1 38.0 1.0
OD1 D:ASP16 4.3 79.4 1.0
CD1 D:LEU19 4.3 47.5 1.0
O D:GLY17 4.5 36.6 1.0
C D:LEU19 4.6 30.4 1.0
C D:ASP16 4.6 51.3 1.0
OG F:SER53 4.7 77.3 1.0
C D:PHE18 4.7 38.3 1.0
CB D:SER20 4.7 35.2 1.0
CA D:PHE18 4.9 37.3 1.0
CA D:SER20 5.0 33.6 1.0

Chlorine binding site 5 out of 8 in 4gum

Go back to Chlorine Binding Sites List in 4gum
Chlorine binding site 5 out of 8 in the Cystal Structure of Locked-Trimer of Human Mif


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Cystal Structure of Locked-Trimer of Human Mif within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl202

b:53.0
occ:1.00
NH1 D:ARG73 3.1 66.8 1.0
CZ D:ARG73 4.3 56.9 1.0
NH2 D:ARG73 4.6 41.1 1.0

Chlorine binding site 6 out of 8 in 4gum

Go back to Chlorine Binding Sites List in 4gum
Chlorine binding site 6 out of 8 in the Cystal Structure of Locked-Trimer of Human Mif


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Cystal Structure of Locked-Trimer of Human Mif within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl203

b:76.3
occ:1.00
NZ D:LYS77 3.1 61.9 1.0
CE D:LYS77 3.7 59.6 1.0
CD D:LYS77 3.7 51.8 1.0
CB D:SER74 3.9 43.9 1.0
CA D:SER74 4.1 38.4 1.0
NE D:ARG73 4.1 50.7 1.0
O D:HOH301 4.2 83.9 1.0
N D:SER74 4.4 36.9 1.0
CG D:ARG73 4.7 40.1 1.0
CD D:ARG73 4.8 45.1 1.0
NH2 D:ARG73 4.8 41.1 1.0
CG D:LYS77 4.9 49.0 1.0
CZ D:ARG73 4.9 56.9 1.0
C D:ARG73 4.9 42.7 1.0
O D:ALA70 4.9 39.9 1.0

Chlorine binding site 7 out of 8 in 4gum

Go back to Chlorine Binding Sites List in 4gum
Chlorine binding site 7 out of 8 in the Cystal Structure of Locked-Trimer of Human Mif


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Cystal Structure of Locked-Trimer of Human Mif within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl201

b:0.9
occ:1.00
ND2 E:ASN102 3.3 67.3 1.0
ND2 E:ASN105 3.8 61.5 1.0
CB E:ASN102 4.1 50.4 1.0
CG E:ASN102 4.2 57.6 1.0
CB E:ASN105 4.5 58.9 1.0
CD1 D:TYR99 4.5 40.1 1.0
CG E:ASN105 4.6 63.0 1.0

Chlorine binding site 8 out of 8 in 4gum

Go back to Chlorine Binding Sites List in 4gum
Chlorine binding site 8 out of 8 in the Cystal Structure of Locked-Trimer of Human Mif


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Cystal Structure of Locked-Trimer of Human Mif within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Cl201

b:58.5
occ:1.00
N I:GLY17 3.4 42.9 1.0
CA I:GLY17 3.4 40.6 1.0
CB I:LEU19 3.8 50.7 1.0
C I:GLY17 3.9 35.1 1.0
N I:LEU19 3.9 39.4 1.0
OG H:SER53 4.0 75.6 1.0
N I:PHE18 4.0 35.5 1.0
CG I:LEU19 4.1 56.9 1.0
OG I:SER20 4.2 41.8 1.0
N I:SER20 4.3 38.0 1.0
OD1 I:ASP16 4.3 80.3 1.0
CA I:LEU19 4.4 38.5 1.0
CD1 I:LEU19 4.5 61.6 1.0
C I:ASP16 4.7 49.6 1.0
O I:GLY17 4.7 41.7 1.0
C I:LEU19 4.8 36.9 1.0
C I:PHE18 4.9 39.0 1.0
CB I:SER20 4.9 35.1 1.0

Reference:

C.Fan, D.Rajasekaran, M.A.Syed, L.Leng, J.P.Loria, V.Bhandari, R.Bucala, E.J.Lolis. Mif Intersubunit Disulfide Mutant Antagonist Supports Activation of CD74 By Endogenous Mif Trimer at Physiologic Concentrations. Proc.Natl.Acad.Sci.Usa V. 110 10994 2013.
ISSN: ISSN 0027-8424
PubMed: 23776208
DOI: 10.1073/PNAS.1221817110
Page generated: Sun Jul 21 15:06:05 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy