Chlorine in PDB 4hkz: Trastuzumab Fab Complexed with Protein L and Protein A Fragments

The structure of Trastuzumab Fab Complexed with Protein L and Protein A Fragments, PDB code: 4hkz was solved by K.N.Avery, C.Zer, K.P.Bzymek, J.C.Williams, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.81 / 2.08
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	53.520, 104.670, 117.550, 90.00, 90.00, 90.00
R / Rfree (%)	16.2 / 20.6

The binding sites of Chlorine atom in the Trastuzumab Fab Complexed with Protein L and Protein A Fragments (pdb code 4hkz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trastuzumab Fab Complexed with Protein L and Protein A Fragments, PDB code: 4hkz:

Chlorine binding site 1 out of 1 in the Trastuzumab Fab Complexed with Protein L and Protein A Fragments


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Trastuzumab Fab Complexed with Protein L and Protein A Fragments within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl301 b:31.3 occ:1.00 NE B:ARG59 3.2 17.7 0.6 N B:TYR60 3.2 12.5 1.0 CE B:LYS65 3.4 50.1 1.0 NZ B:LYS65 3.6 37.9 1.0 CA B:ARG59 3.7 17.5 0.6 CA B:ARG59 3.7 17.4 0.4 CD B:ARG59 3.8 18.9 0.6 C B:ARG59 4.0 17.5 1.0 O B:TYR60 4.0 15.8 1.0 CA B:TYR60 4.2 12.7 1.0 CB B:ARG59 4.2 17.7 0.6 CZ B:ARG59 4.2 20.3 0.6 CD2 B:TYR60 4.2 18.9 1.0 CD B:ARG59 4.2 21.6 0.4 CB B:TYR60 4.3 19.0 1.0 CB B:ARG59 4.3 17.4 0.4 NH2 B:ARG59 4.3 18.4 0.6 C B:TYR60 4.5 15.0 1.0 CD B:LYS65 4.6 49.3 1.0 O B:THR58 4.6 13.7 1.0 CG B:ARG59 4.7 20.4 0.6 NE2 H:GLN38 4.7 24.0 1.0 CG B:TYR60 4.8 21.2 1.0 CG B:LYS65 4.8 39.5 1.0 O B:HOH605 4.9 33.6 1.0 CG B:ARG59 4.9 19.5 0.4 N B:ARG59 4.9 15.4 1.0

J.M.Donaldson, C.Zer, K.N.Avery, K.P.Bzymek, D.A.Horne, J.C.Williams. Identification and Grafting of A Unique Peptide-Binding Site in the Fab Framework of Monoclonal Antibodies. Proc.Natl.Acad.Sci.Usa V. 110 17456 2013.
ISSN: ISSN 0027-8424
PubMed: 24101516
DOI: 10.1073/PNAS.1307309110