Chlorine in PDB 4ix8: Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum

All present enzymatic activity of Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum:
2.6.1.5;

The structure of Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum, PDB code: 4ix8 was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.14 / 2.35
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	98.960, 98.960, 199.260, 90.00, 90.00, 120.00
R / Rfree (%)	17.3 / 20.6

The binding sites of Chlorine atom in the Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum (pdb code 4ix8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum, PDB code: 4ix8:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:46.1 occ:1.00 O A:HOH778 2.8 49.9 1.0 HE21 A:GLN152 3.0 41.2 1.0 HG23 A:ILE321 3.3 35.6 1.0 HG11 A:VAL155 3.4 29.3 1.0 HG21 B:ILE321 3.4 36.0 1.0 HG3 A:GLN152 3.4 35.5 1.0 O A:HOH621 3.6 28.0 1.0 HG21 A:ILE321 3.6 35.6 1.0 NE2 A:GLN152 3.8 34.3 1.0 HG22 B:ILE321 3.8 36.0 1.0 HG23 B:ILE321 3.9 36.0 1.0 CG2 B:ILE321 3.9 30.0 1.0 CL B:CL501 3.9 53.9 1.0 CG2 A:ILE321 3.9 29.7 1.0 HG2 A:GLN152 4.1 35.5 1.0 CG A:GLN152 4.1 29.6 1.0 HG12 A:ILE321 4.2 33.9 1.0 HD13 A:ILE321 4.2 35.8 1.0 CG1 A:VAL155 4.2 24.4 1.0 HG12 A:VAL155 4.2 29.3 1.0 HB2 A:LEU320 4.3 40.1 1.0 HE22 A:GLN152 4.3 41.2 1.0 HD21 A:LEU156 4.4 28.8 1.0 CD A:GLN152 4.5 27.8 1.0 HB A:VAL155 4.5 38.7 1.0 HG22 A:ILE321 4.5 35.6 1.0 HD23 A:LEU156 4.8 28.8 1.0 HG21 A:VAL155 4.8 30.1 1.0 HG A:LEU156 4.8 37.2 1.0 CG1 A:ILE321 4.8 28.2 1.0 H A:ILE321 4.8 38.5 1.0 HD12 A:LEU320 4.9 38.6 1.0 O A:HOH679 4.9 34.6 1.0 CD1 A:ILE321 4.9 29.9 1.0 CB A:VAL155 4.9 32.3 1.0 HG13 A:VAL155 4.9 29.3 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Tyrosine Aminotransferase From Leishmania Infantum within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl501 b:53.9 occ:1.00 HE21 B:GLN152 2.7 32.0 1.0 O B:HOH623 3.4 28.2 1.0 HG11 B:VAL155 3.4 39.5 1.0 HG23 B:ILE321 3.5 36.0 1.0 HG3 B:GLN152 3.5 36.6 1.0 NE2 B:GLN152 3.6 26.7 1.0 HG21 A:ILE321 3.7 35.6 1.0 HD21 B:LEU156 3.8 31.8 1.0 HG2 B:GLN152 3.9 36.6 1.0 CL A:CL501 3.9 46.1 1.0 HG21 B:ILE321 3.9 36.0 1.0 HG12 B:VAL155 4.0 39.5 1.0 HG22 A:ILE321 4.0 35.6 1.0 CG B:GLN152 4.0 30.5 1.0 HG12 B:ILE321 4.1 29.7 1.0 HE22 B:GLN152 4.1 32.0 1.0 CG2 B:ILE321 4.1 30.0 1.0 CG1 B:VAL155 4.2 33.0 1.0 CG2 A:ILE321 4.2 29.7 1.0 HB2 B:LEU320 4.2 28.3 1.0 HG23 A:ILE321 4.2 35.6 1.0 HD23 B:LEU156 4.3 31.8 1.0 HG B:LEU156 4.3 40.7 1.0 CD B:GLN152 4.3 30.3 1.0 HD13 B:ILE321 4.4 32.4 1.0 HB B:VAL155 4.4 37.9 1.0 CD2 B:LEU156 4.5 26.5 1.0 HD12 B:LEU320 4.5 34.2 1.0 O B:LEU317 4.7 28.2 1.0 HG22 B:ILE321 4.8 36.0 1.0 CG1 B:ILE321 4.8 24.8 1.0 H B:ILE321 4.9 26.8 1.0 CB B:VAL155 4.9 31.6 1.0 HG13 B:VAL155 4.9 39.5 1.0 O B:HOH655 4.9 40.0 1.0 CG B:LEU156 4.9 33.9 1.0 HG21 B:VAL155 5.0 37.2 1.0 CD1 B:ILE321 5.0 27.0 1.0

M.A.Moreno, A.Abramov, J.Abendroth, A.Alonso, S.Zhang, P.J.Alcolea, T.Edwards, D.Lorimer, P.J.Myler, V.Larraga. Structure of Tyrosine Aminotransferase From Leishmania Infantum. Acta Crystallogr F Struct V. 70 583 2014BIOL Commun.
PubMed: 24817714
DOI: 10.1107/S2053230X14007845