Atomistry » Chlorine » PDB 4li5-4lqz » 4lqm
Atomistry »
  Chlorine »
    PDB 4li5-4lqz »
      4lqm »

Chlorine in PDB 4lqm: Egfr L858R in Complex with PD168393

Enzymatic activity of Egfr L858R in Complex with PD168393

All present enzymatic activity of Egfr L858R in Complex with PD168393:
2.7.10.1;

Protein crystallography data

The structure of Egfr L858R in Complex with PD168393, PDB code: 4lqm was solved by C.H.Yun, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.50
Space group I 2 3
Cell size a, b, c (Å), α, β, γ (°) 146.173, 146.173, 146.173, 90.00, 90.00, 90.00
R / Rfree (%) 18.4 / 22.8

Other elements in 4lqm:

The structure of Egfr L858R in Complex with PD168393 also contains other interesting chemical elements:

Bromine (Br) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Egfr L858R in Complex with PD168393 (pdb code 4lqm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Egfr L858R in Complex with PD168393, PDB code: 4lqm:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4lqm

Go back to Chlorine Binding Sites List in 4lqm
Chlorine binding site 1 out of 2 in the Egfr L858R in Complex with PD168393


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Egfr L858R in Complex with PD168393 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1102

b:75.4
occ:1.00
N A:ILE878 3.5 58.6 1.0
N A:LYS879 3.6 49.2 1.0
CG A:LYS879 3.9 48.3 1.0
CB A:LYS879 4.0 49.2 1.0
CZ3 A:TRP880 4.0 41.2 1.0
O A:HOH1265 4.0 61.2 1.0
C A:PRO877 4.1 63.6 1.0
CD A:LYS879 4.1 47.2 1.0
CA A:PRO877 4.1 62.3 1.0
CA A:ILE878 4.3 57.4 1.0
CE3 A:TRP880 4.4 41.7 1.0
CB A:ILE878 4.4 58.0 1.0
O A:VAL876 4.4 73.0 1.0
CA A:LYS879 4.4 49.0 1.0
C A:ILE878 4.5 52.4 1.0
CE A:LYS879 4.8 50.9 1.0
O A:HOH1300 4.8 64.4 1.0
CG1 A:ILE878 5.0 61.1 1.0

Chlorine binding site 2 out of 2 in 4lqm

Go back to Chlorine Binding Sites List in 4lqm
Chlorine binding site 2 out of 2 in the Egfr L858R in Complex with PD168393


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Egfr L858R in Complex with PD168393 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1103

b:88.2
occ:1.00
NZ A:LYS913 3.5 80.1 1.0
NE A:ARG803 4.0 44.8 1.0
CZ A:ARG803 4.2 44.3 1.0
CD A:ARG803 4.4 41.6 1.0
NH2 A:ARG803 4.5 42.9 1.0
O A:GLY911 4.7 58.0 1.0
O A:HOH1237 4.7 56.0 1.0
CG A:ARG803 4.8 41.0 1.0
NH1 A:ARG803 4.8 48.0 1.0
CE A:LYS913 4.9 76.5 1.0

Reference:

H.Yasuda, E.Park, C.H.Yun, N.J.Sng, A.R.Lucena-Araujo, W.L.Yeo, M.S.Huberman, D.W.Cohen, S.Nakayama, K.Ishioka, N.Yamaguchi, M.Hanna, G.R.Oxnard, C.S.Lathan, T.Moran, L.V.Sequist, J.E.Chaft, G.J.Riely, M.E.Arcila, R.A.Soo, M.Meyerson, M.J.Eck, S.S.Kobayashi, D.B.Costa. Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (Egfr) Exon 20 Insertion Mutations in Lung Cancer. Sci Transl Med V. 5 RA177 2013.
ISSN: ISSN 1946-6234
PubMed: 24353160
DOI: 10.1126/SCITRANSLMED.3007205
Page generated: Sun Jul 21 19:09:25 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy