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Chlorine in PDB 4m3q: Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
Enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917, PDB code: 4m3q
was solved by
W.Zhang,
D.Zhang,
M.A.Stashko,
D.Deryckere,
D.Hunter,
D.B.Kireev,
M.Miley,
C.Cummings,
M.Lee,
J.Norris-Drouin,
W.M.Stewart,
S.Sather,
Y.Zhou,
G.Kirkpatrick,
M.Machius,
W.P.Janzen,
H.S.Earp,
D.K.Graham,
S.Frye,
X.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 34.74 / 2.72 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 50.924, 91.120, 69.699, 90.00, 99.81, 90.00 |
| R / Rfree (%) | 24.3 / 29.6 |
Other elements in 4m3q:
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917 also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
(pdb code 4m3q). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917, PDB code: 4m3q:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;
In total 7 binding sites of Chlorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917, PDB code: 4m3q:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;
Chlorine binding site 1 out of 7 in 4m3q
Go back to
Chlorine Binding Sites List in 4m3q
Chlorine binding site 1 out
of 7 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917 within 5.0Å range:
|
Chlorine binding site 2 out of 7 in 4m3q
Go back to
Chlorine Binding Sites List in 4m3q
Chlorine binding site 2 out
of 7 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917 within 5.0Å range:
|
Chlorine binding site 3 out of 7 in 4m3q
Go back to
Chlorine Binding Sites List in 4m3q
Chlorine binding site 3 out
of 7 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917 within 5.0Å range:
|
Chlorine binding site 4 out of 7 in 4m3q
Go back to
Chlorine Binding Sites List in 4m3q
Chlorine binding site 4 out
of 7 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917 within 5.0Å range:
|
Chlorine binding site 5 out of 7 in 4m3q
Go back to
Chlorine Binding Sites List in 4m3q
Chlorine binding site 5 out
of 7 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917 within 5.0Å range:
|
Chlorine binding site 6 out of 7 in 4m3q
Go back to
Chlorine Binding Sites List in 4m3q
Chlorine binding site 6 out
of 7 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917 within 5.0Å range:
|
Chlorine binding site 7 out of 7 in 4m3q
Go back to
Chlorine Binding Sites List in 4m3q
Chlorine binding site 7 out
of 7 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1917 within 5.0Å range:
|
Reference:
W.Zhang,
D.Zhang,
M.A.Stashko,
D.Deryckere,
D.Hunter,
D.Kireev,
M.J.Miley,
C.Cummings,
M.Lee,
J.Norris-Drouin,
W.M.Stewart,
S.Sather,
Y.Zhou,
G.Kirkpatrick,
M.Machius,
W.P.Janzen,
H.S.Earp,
D.K.Graham,
S.V.Frye,
X.Wang.
Pseudo-Cyclization Through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines As New Mer Kinase Inhibitors. J.Med.Chem. V. 56 9683 2013.
ISSN: ISSN 0022-2623
PubMed: 24195762
DOI: 10.1021/JM401387J
Page generated: Fri Jul 11 18:55:17 2025
ISSN: ISSN 0022-2623
PubMed: 24195762
DOI: 10.1021/JM401387J
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