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Chlorine in PDB 4mha: Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
Enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817, PDB code: 4mha
was solved by
W.Zhang,
A.Mciver,
M.A.Stashko,
D.Deryckere,
B.R.Branchford,
D.Hunter,
D.B.Kireev,
D.B.M.Miley,
J.Norris-Drouin,
W.M.Stewart,
M.Lee,
S.Sather,
Y.Zhou,
J.A.Dipaola,
M.Machius,
W.P.Janzen,
H.S.Earp,
D.K.Graham,
S.Frye,
X.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 40.07 / 2.59 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.142, 91.460, 69.932, 90.00, 100.23, 90.00 |
| R / Rfree (%) | 24.1 / 29.4 |
Other elements in 4mha:
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817 also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
(pdb code 4mha). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817, PDB code: 4mha:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Chlorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817, PDB code: 4mha:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
Chlorine binding site 1 out of 6 in 4mha
Go back to
Chlorine Binding Sites List in 4mha
Chlorine binding site 1 out
of 6 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817 within 5.0Å range:
|
Chlorine binding site 2 out of 6 in 4mha
Go back to
Chlorine Binding Sites List in 4mha
Chlorine binding site 2 out
of 6 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817 within 5.0Å range:
|
Chlorine binding site 3 out of 6 in 4mha
Go back to
Chlorine Binding Sites List in 4mha
Chlorine binding site 3 out
of 6 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817 within 5.0Å range:
|
Chlorine binding site 4 out of 6 in 4mha
Go back to
Chlorine Binding Sites List in 4mha
Chlorine binding site 4 out
of 6 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817 within 5.0Å range:
|
Chlorine binding site 5 out of 6 in 4mha
Go back to
Chlorine Binding Sites List in 4mha
Chlorine binding site 5 out
of 6 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817 within 5.0Å range:
|
Chlorine binding site 6 out of 6 in 4mha
Go back to
Chlorine Binding Sites List in 4mha
Chlorine binding site 6 out
of 6 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC1817 within 5.0Å range:
|
Reference:
W.Zhang,
A.L.Mciver,
M.A.Stashko,
D.Deryckere,
B.R.Branchford,
D.Hunter,
D.Kireev,
M.J.Miley,
J.Norris-Drouin,
W.M.Stewart,
M.Lee,
S.Sather,
Y.Zhou,
J.A.Di Paola,
M.Machius,
W.P.Janzen,
H.S.Earp,
D.K.Graham,
S.V.Frye,
X.Wang.
Discovery of Mer Specific Tyrosine Kinase Inhibitors For the Treatment and Prevention of Thrombosis. J.Med.Chem. V. 56 9693 2013.
ISSN: ISSN 0022-2623
PubMed: 24219778
DOI: 10.1021/JM4013888
Page generated: Fri Jul 11 19:06:20 2025
ISSN: ISSN 0022-2623
PubMed: 24219778
DOI: 10.1021/JM4013888
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