Chlorine in PDB 4mne: Crystal Structure of the Braf:MEK1 Complex

All present enzymatic activity of Crystal Structure of the Braf:MEK1 Complex:
2.7.11.1; 2.7.12.2;

The structure of Crystal Structure of the Braf:MEK1 Complex, PDB code: 4mne was solved by J.Sudhamsu, J.R.Haling, T.Morales, B.Brandhuber, S.G.Hymowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.59 / 2.85
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	97.498, 135.657, 256.059, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 24

The structure of Crystal Structure of the Braf:MEK1 Complex also contains other interesting chemical elements:

Fluorine	(F)	10 atoms
Magnesium	(Mg)	4 atoms
Iodine	(I)	5 atoms

The binding sites of Chlorine atom in the Crystal Structure of the Braf:MEK1 Complex (pdb code 4mne). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Braf:MEK1 Complex, PDB code: 4mne:

Chlorine binding site 1 out of 1 in the Crystal Structure of the Braf:MEK1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl801 b:72.0 occ:1.00 NZ F:LYS591 3.4 22.8 1.0 NZ G:LYS591 3.6 28.2 1.0 O G:HOH810 3.7 29.4 1.0 CG1 G:VAL511 4.3 29.7 1.0 NE2 G:GLN530 4.4 30.9 1.0 CE F:LYS591 4.5 27.7 1.0 NE2 F:GLN530 4.5 33.4 1.0 CE G:LYS591 4.7 25.5 1.0 OE1 F:GLN530 4.9 35.2 1.0 CB G:VAL511 4.9 22.1 1.0 CG1 F:VAL511 4.9 31.6 1.0

J.R.Haling, J.Sudhamsu, I.Yen, S.Sideris, W.Sandoval, W.Phung, B.J.Bravo, A.M.Giannetti, A.Peck, A.Masselot, T.Morales, D.Smith, B.J.Brandhuber, S.G.Hymowitz, S.Malek. Structure of the Braf-Mek Complex Reveals A Kinase Activity Independent Role For Braf in Mapk Signaling. Cancer Cell V. 26 402 2014.
ISSN: ISSN 1535-6108
PubMed: 25155755
DOI: 10.1016/J.CCR.2014.07.007