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Chlorine in PDB 4n3m: Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine

Enzymatic activity of Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine

All present enzymatic activity of Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine:
1.7.3.3;

Protein crystallography data

The structure of Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine, PDB code: 4n3m was solved by E.Oksanen, M.P.Blakeley, M.Budayova-Spano, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 1.90
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 80.200, 96.200, 105.500, 90.00, 90.00, 90.00
R / Rfree (%) 14 / 17.2

Other elements in 4n3m:

The structure of Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine also contains other interesting chemical elements:

Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine (pdb code 4n3m). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine, PDB code: 4n3m:

Chlorine binding site 1 out of 1 in 4n3m

Go back to Chlorine Binding Sites List in 4n3m
Chlorine binding site 1 out of 1 in the Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Joint Neutron/X-Ray Structure of Urate Oxidase in Complex with 8- Azaxanthine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl402

b:30.9
occ:1.00
DD21 A:ASN254 2.2 23.7 1.0
HA3 A:GLY286 2.5 17.7 1.0
HE1 A:HIS256 2.8 23.7 1.0
HB3 A:ASN254 2.9 17.1 1.0
ND2 A:ASN254 3.1 22.9 1.0
HB2 A:ASN254 3.4 18.7 1.0
CA A:GLY286 3.4 16.4 1.0
C4 A:AZA401 3.4 18.1 1.0
CB A:ASN254 3.5 16.0 1.0
C5 A:AZA401 3.5 16.3 1.0
HA2 A:GLY286 3.6 14.2 1.0
N9 A:AZA401 3.6 18.6 1.0
CE1 A:HIS256 3.6 21.8 1.0
HD12 A:ILE288 3.7 18.5 1.0
DD22 A:ASN254 3.7 23.1 1.0
H A:GLY286 3.7 19.6 0.1
D A:GLY286 3.7 19.6 0.9
CG A:ASN254 3.7 21.5 1.0
N7 A:AZA401 3.7 18.0 1.0
N8 A:AZA401 3.8 19.4 1.0
N3 A:AZA401 3.9 18.2 1.0
DN9 A:AZA401 4.0 20.9 1.0
C6 A:AZA401 4.0 17.1 1.0
N A:GLY286 4.0 16.9 1.0
NE2 A:HIS256 4.1 22.5 1.0
C2 A:AZA401 4.4 14.4 1.0
N1 A:AZA401 4.4 16.0 1.0
C A:GLY286 4.5 17.9 1.0
CD1 A:ILE288 4.5 25.5 1.0
HD13 A:ILE288 4.5 19.4 1.0
O6 A:AZA401 4.7 17.8 1.0
HG12 A:ILE288 4.8 18.8 1.0
ND1 A:HIS256 4.8 25.6 1.0
CA A:ASN254 4.9 13.5 1.0
H A:ASN254 4.9 17.4 0.0
D A:ASN254 4.9 17.4 1.0
OD1 A:ASN254 4.9 20.0 1.0
H A:LEU287 4.9 17.1 0.0
D A:LEU287 4.9 17.1 1.0
O A:DOD633 4.9 18.4 1.0
HG13 A:ILE288 5.0 21.3 1.0

Reference:

E.Oksanen, M.P.Blakeley, M.El-Hajji, U.Ryde, M.Budayova-Spano. The Neutron Structure of Urate Oxidase Resolves A Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation. Plos One V. 9 86651 2014.
ISSN: ESSN 1932-6203
PubMed: 24466188
DOI: 10.1371/JOURNAL.PONE.0086651
Page generated: Fri Jul 11 19:28:04 2025

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