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Chlorine in PDB 4n9s: High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine

Enzymatic activity of High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine

All present enzymatic activity of High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine:
1.7.3.3;

Protein crystallography data

The structure of High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine, PDB code: 4n9s was solved by E.Oksanen, M.P.Blakeley, M.Budayova-Spano, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.27 / 1.06
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 79.930, 95.370, 104.810, 90.00, 90.00, 90.00
R / Rfree (%) 12.6 / 14.1

Other elements in 4n9s:

The structure of High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine also contains other interesting chemical elements:

Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine (pdb code 4n9s). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine, PDB code: 4n9s:

Chlorine binding site 1 out of 1 in 4n9s

Go back to Chlorine Binding Sites List in 4n9s
Chlorine binding site 1 out of 1 in the High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of High Resolution X-Ray Structure of Urate Oxidase in Complex with 8- Hydroxyxanthine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:10.2
occ:0.83
 DD21 A:ASN254 2.3 12.8 1.0
HA3 A:GLY286 2.5 9.2 1.0
HE1 A:HIS256 2.9 10.1 1.0
HB3 A:ASN254 3.0 9.2 1.0
HD11 A:ILE288 3.2 15.9 1.0
ND2 A:ASN254 3.2 10.7 1.0
C4 A:8HX403 3.2 11.4 0.8
HB2 A:ASN254 3.3 9.2 1.0
C5 A:8HX403 3.3 10.7 0.8
CA A:GLY286 3.5 7.6 1.0
CB A:ASN254 3.5 7.7 1.0
N9 A:8HX403 3.6 10.7 0.8
N3 A:8HX403 3.6 9.4 0.8
HA2 A:GLY286 3.7 9.2 1.0
N7 A:8HX403 3.7 12.8 0.8
C6 A:8HX403 3.7 11.5 0.8
CE1 A:HIS256 3.8 8.4 1.0
C8 A:8HX403 3.8 9.2 0.8
CG A:ASN254 3.8 9.0 1.0
D A:GLY286 3.9 8.9 1.0
DD22 A:ASN254 3.9 12.8 1.0
C2 A:8HX403 4.0 10.8 0.8
N1 A:8HX403 4.0 10.4 0.8
DAB A:8HX403 4.1 12.8 0.8
CD1 A:ILE288 4.2 13.2 1.0
DE2 A:HIS256 4.2 10.7 1.0
N A:GLY286 4.2 7.4 1.0
NE2 A:HIS256 4.4 8.9 1.0
O6 A:8HX403 4.4 11.4 0.8
C A:GLY286 4.5 7.2 1.0
HD13 A:ILE288 4.5 15.9 1.0
HG12 A:ILE288 4.6 12.9 1.0
HD12 A:ILE288 4.6 15.9 1.0
HG13 A:ILE288 4.7 12.9 1.0
O8 A:8HX403 4.7 24.8 0.8
DAC A:8HX403 4.7 12.5 0.8
CG1 A:ILE288 4.8 10.7 1.0
D A:LEU287 4.8 8.4 1.0
D A:ASN254 4.8 8.6 0.5
O2 A:8HX403 4.8 10.1 0.8
DH12 A:ARG176 4.9 11.3 1.0
CA A:ASN254 4.9 7.0 1.0
ND1 A:HIS256 4.9 8.0 1.0
N A:LEU287 4.9 7.0 1.0
DAA A:8HX403 5.0 29.8 0.8
HG21 A:VAL227 5.0 11.6 1.0

Reference:

E.Oksanen, M.P.Blakeley, M.El-Hajji, U.Ryde, M.Budayova-Spano. The Neutron Structure of Urate Oxidase Resolves A Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation. Plos One V. 9 86651 2014.
ISSN: ESSN 1932-6203
PubMed: 24466188
DOI: 10.1371/JOURNAL.PONE.0086651
Page generated: Fri Jul 11 19:31:57 2025

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