Chlorine in PDB 4no7: Human Glucokinase in Complex with A Nanomolar Activator.

All present enzymatic activity of Human Glucokinase in Complex with A Nanomolar Activator.:
2.7.1.2;

The structure of Human Glucokinase in Complex with A Nanomolar Activator., PDB code: 4no7 was solved by P.Petit, G.Ferry, M.Antoine, J.A.Boutin, A.Kotschy, F.Perron-Sierra, L.Mamelli, L.Vuillard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.74 / 1.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	66.300, 81.300, 85.500, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 22.3

The binding sites of Chlorine atom in the Human Glucokinase in Complex with A Nanomolar Activator. (pdb code 4no7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Glucokinase in Complex with A Nanomolar Activator., PDB code: 4no7:

Chlorine binding site 1 out of 1 in the Human Glucokinase in Complex with A Nanomolar Activator.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Glucokinase in Complex with A Nanomolar Activator. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:35.2 occ:1.00 CL26 A:2N8502 0.0 35.2 1.0 C24 A:2N8502 1.8 32.7 1.0 C25 A:2N8502 2.7 30.9 1.0 C23 A:2N8502 2.7 33.7 1.0 O29 A:2N8502 3.0 34.6 1.0 S27 A:2N8502 3.2 36.1 1.0 O30 A:2N8502 3.4 37.7 1.0 CD1 A:TYR215 3.7 27.6 1.0 C22 A:2N8502 3.8 32.6 1.0 CG2 A:ILE211 3.9 17.3 1.0 C10 A:2N8502 4.0 29.4 1.0 CB A:TYR215 4.0 25.3 1.0 O A:ILE211 4.1 16.6 1.0 CD2 A:TYR214 4.1 19.1 1.0 CB A:LEU451 4.2 26.6 1.0 CA A:TYR215 4.2 24.7 1.0 CG A:TYR215 4.3 26.8 1.0 C21 A:2N8502 4.3 31.1 1.0 N A:TYR215 4.4 23.1 1.0 CG2 A:VAL455 4.5 33.0 1.0 CD1 A:LEU451 4.5 28.5 1.0 CE2 A:TYR214 4.6 19.4 1.0 CE1 A:TYR215 4.6 29.6 1.0 CG A:LEU451 4.7 27.7 1.0 CD2 A:LEU451 4.8 28.5 1.0 C28 A:2N8502 4.8 35.6 1.0 C A:ILE211 4.9 17.3 1.0

P.Petit, M.Antoine, G.Ferry, J.A.Boutin, A.Lagarde, L.Gluais, R.Vincentelli, L.Vuillard. The Active Conformation of Human Glucokinase Is Not Altered By Allosteric Activators. Acta Crystallogr.,Sect.D 2014.
ISSN: ESSN 1399-0047
DOI: 10.1107/S0907444911036729