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Chlorine in PDB 4occ: Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48
Protein crystallography data
The structure of Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48, PDB code: 4occ
was solved by
X.Huang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 1.80 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 56.584, 98.785, 106.819, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.6 / 21.6 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48
(pdb code 4occ). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48, PDB code: 4occ:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Chlorine where determined in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48, PDB code: 4occ:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
Chlorine binding site 1 out of 6 in 4occ
Go back to
Chlorine Binding Sites List in 4occ
Chlorine binding site 1 out
of 6 in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48 within 5.0Å range:
|
Chlorine binding site 2 out of 6 in 4occ
Go back to
Chlorine Binding Sites List in 4occ
Chlorine binding site 2 out
of 6 in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48 within 5.0Å range:
|
Chlorine binding site 3 out of 6 in 4occ
Go back to
Chlorine Binding Sites List in 4occ
Chlorine binding site 3 out
of 6 in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48 within 5.0Å range:
|
Chlorine binding site 4 out of 6 in 4occ
Go back to
Chlorine Binding Sites List in 4occ
Chlorine binding site 4 out
of 6 in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48 within 5.0Å range:
|
Chlorine binding site 5 out of 6 in 4occ
Go back to
Chlorine Binding Sites List in 4occ
Chlorine binding site 5 out
of 6 in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48 within 5.0Å range:
|
Chlorine binding site 6 out of 6 in 4occ
Go back to
Chlorine Binding Sites List in 4occ
Chlorine binding site 6 out
of 6 in the Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Co-Crystal Structure of MDM2(17-111) in Complex with Compound 48 within 5.0Å range:
|
Reference:
A.Z.Gonzalez,
Z.Li,
H.P.Beck,
J.Canon,
A.Chen,
D.Chow,
J.Duquette,
J.Eksterowicz,
B.M.Fox,
J.Fu,
X.Huang,
J.Houze,
L.Jin,
Y.Li,
Y.Ling,
M.C.Lo,
A.M.Long,
L.R.Mcgee,
J.Mcintosh,
J.D.Oliner,
T.Osgood,
Y.Rew,
A.Y.Saiki,
P.Shaffer,
S.Wortman,
P.Yakowec,
X.Yan,
Q.Ye,
D.Yu,
X.Zhao,
J.Zhou,
S.H.Olson,
D.Sun,
J.C.Medina.
Novel Inhibitors of the MDM2-P53 Interaction Featuring Hydrogen Bond Acceptors As Carboxylic Acid Isosteres. J.Med.Chem. V. 57 2963 2014.
ISSN: ISSN 0022-2623
PubMed: 24601644
DOI: 10.1021/JM401911V
Page generated: Fri Jul 11 19:59:49 2025
ISSN: ISSN 0022-2623
PubMed: 24601644
DOI: 10.1021/JM401911V
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