Chlorine in PDB 4pir: X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor

The structure of X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor, PDB code: 4pir was solved by G.Hassaine, C.Deluz, L.Grasso, R.Wyss, M.B.Tol, R.Hovius, A.Graff, H.Stahlberg, T.Tomizaki, A.Desmyter, C.Moreau, X.-D.Li, F.Poitevin, H.Vogel, H.Nury, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	121.542, 187.087, 240.554, 90.00, 90.00, 90.00
R / Rfree (%)	21.7 / 25.7

The binding sites of Chlorine atom in the X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor (pdb code 4pir). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor, PDB code: 4pir:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl508 b:0.9 occ:1.00 NH1 A:ARG31 2.6 0.4 1.0 NH2 A:ARG31 3.1 0.2 1.0 CZ A:ARG31 3.3 0.3 1.0 NZ A:LYS35 3.4 0.6 1.0 CE A:LYS35 4.5 0.8 1.0 NE A:ARG31 4.6 0.8 1.0 OE2 A:GLU71 4.8 0.7 1.0 OE1 A:GLU71 5.0 0.7 1.0

Chlorine binding site 2 out of 5 in the X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl508 b:84.3 occ:1.00 NE B:ARG31 3.5 0.5 1.0 NZ B:LYS35 3.6 0.2 1.0 NH2 B:ARG31 3.8 0.9 1.0 CZ B:ARG31 4.1 0.8 1.0 CD B:ARG31 4.5 91.1 1.0 OE2 B:GLU71 4.7 0.8 1.0 CE B:LYS35 4.8 0.9 1.0 CD B:GLU71 4.8 0.3 1.0 OE1 B:GLU71 4.9 0.8 1.0 CB B:ARG31 4.9 79.3 1.0

Chlorine binding site 3 out of 5 in the X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl508 b:71.0 occ:1.00 NH1 C:ARG31 2.5 0.1 1.0 NH2 C:ARG31 3.0 0.2 1.0 CZ C:ARG31 3.2 0.3 1.0 NZ C:LYS35 3.3 78.4 1.0 CE C:LYS35 4.5 0.8 1.0 NE C:ARG31 4.5 98.5 1.0 OE2 C:GLU71 4.7 1.0 1.0 OE1 C:GLU71 4.9 0.1 1.0 CD C:GLU71 4.9 0.7 1.0

Chlorine binding site 4 out of 5 in the X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl509 b:88.2 occ:1.00 NH1 D:ARG31 2.7 0.6 1.0 NZ D:LYS35 2.9 0.7 1.0 NH2 D:ARG31 3.0 0.4 1.0 CZ D:ARG31 3.3 0.0 1.0 CE D:LYS35 4.0 0.2 1.0 OE2 D:GLU71 4.4 0.9 1.0 NE D:ARG31 4.6 0.8 1.0 OE1 D:GLU71 4.6 99.7 1.0 CD D:GLU71 4.6 95.0 1.0

Chlorine binding site 5 out of 5 in the X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl508 b:87.7 occ:1.00 NH1 E:ARG31 2.3 0.4 1.0 CZ E:ARG31 3.2 0.6 1.0 NH2 E:ARG31 3.3 0.9 1.0 NZ E:LYS35 3.9 0.0 1.0 NE E:ARG31 4.5 69.2 1.0

G.Hassaine, C.Deluz, L.Grasso, R.Wyss, M.B.Tol, R.Hovius, A.Graff, H.Stahlberg, T.Tomizaki, A.Desmyter, C.Moreau, X.D.Li, F.Poitevin, H.Vogel, H.Nury. X-Ray Structure of the Mouse Serotonin 5-HT3 Receptor. Nature V. 512 276 2014.
ISSN: ESSN 1476-4687
PubMed: 25119048
DOI: 10.1038/NATURE13552