Chlorine in PDB 4q93: Resveratrol Bound at the Active Site of Human Tyrosyl Trna Synthetase

All present enzymatic activity of Resveratrol Bound at the Active Site of Human Tyrosyl Trna Synthetase:
6.1.1.1;

The structure of Resveratrol Bound at the Active Site of Human Tyrosyl Trna Synthetase, PDB code: 4q93 was solved by S.Mathew, P.Schimmel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.01 / 2.10
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	73.966, 162.550, 35.014, 90.00, 90.00, 90.00
R / Rfree (%)	17.4 / 23.1

The binding sites of Chlorine atom in the Resveratrol Bound at the Active Site of Human Tyrosyl Trna Synthetase (pdb code 4q93). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Resveratrol Bound at the Active Site of Human Tyrosyl Trna Synthetase, PDB code: 4q93:

Chlorine binding site 1 out of 1 in the Resveratrol Bound at the Active Site of Human Tyrosyl Trna Synthetase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Resveratrol Bound at the Active Site of Human Tyrosyl Trna Synthetase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl408 b:51.7 occ:1.00 O A:HOH725 2.2 41.6 1.0 NZ A:LYS265 3.0 42.0 1.0 O A:HOH726 3.0 48.0 1.0 O A:HOH710 3.3 43.9 1.0 NE2 A:HIS266 3.6 28.2 1.0 O A:HOH722 3.6 52.5 1.0 CE A:LYS265 3.8 37.0 1.0 CG A:PRO213 4.0 31.6 1.0 CD A:LYS265 4.1 32.2 1.0 CE1 A:HIS266 4.2 27.9 1.0 O1 A:PO4412 4.5 72.9 1.0 CB A:PRO213 4.5 27.4 1.0 O3 A:PO4412 4.5 64.8 1.0 CD2 A:HIS266 4.7 25.2 1.0

M.Sajish, P.Schimmel. A Human Trna Synthetase Is A Potent PARP1-Activating Effector Target For Resveratrol Nature 2014.
ISSN: ESSN 1476-4687
DOI: 10.1038/NATURE14028