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Chlorine in PDB 4r7h: Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397
Enzymatic activity of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397
All present enzymatic activity of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397, PDB code: 4r7h
was solved by
Y.Zhang,
K.Zhang,
C.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 52.62 / 2.80 |
| Space group | P 43 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 63.984, 63.984, 185.041, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 22.1 / 24.8 |
Other elements in 4r7h:
The structure of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397 also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397
(pdb code 4r7h). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397, PDB code: 4r7h:
In total only one binding site of Chlorine was determined in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397, PDB code: 4r7h:
Chlorine binding site 1 out of 1 in 4r7h
Go back to
Chlorine Binding Sites List in 4r7h
Chlorine binding site 1 out
of 1 in the Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Fms Kinase Domain with A Small Molecular Inhibitor, PLX3397 within 5.0Å range:
|
Reference:
W.D.Tap,
Z.A.Wainberg,
S.P.Anthony,
P.N.Ibrahim,
C.Zhang,
J.H.Healey,
B.Chmielowski,
A.P.Staddon,
A.L.Cohn,
G.I.Shapiro,
V.L.Keedy,
A.S.Singh,
I.Puzanov,
E.L.Kwak,
A.J.Wagner,
D.D.Von Hoff,
G.J.Weiss,
R.K.Ramanathan,
J.Zhang,
G.Habets,
Y.Zhang,
E.A.Burton,
G.Visor,
L.Sanftner,
P.Severson,
H.Nguyen,
M.J.Kim,
A.Marimuthu,
G.Tsang,
R.Shellooe,
C.Gee,
B.L.West,
P.Hirth,
K.Nolop,
M.Van De Rijn,
H.H.Hsu,
C.Peterfy,
P.S.Lin,
S.Tong-Starksen,
G.Bollag.
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. N Engl J Med V. 373 428 2015.
PubMed: 26222558
DOI: 10.1056/NEJMOA1411366
Page generated: Fri Jul 26 01:09:26 2024
PubMed: 26222558
DOI: 10.1056/NEJMOA1411366
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