Chlorine in PDB 4u2x: Ebola Virus VP24 in Complex with Karyopherin Alpha 5 C-Terminus

The structure of Ebola Virus VP24 in Complex with Karyopherin Alpha 5 C-Terminus, PDB code: 4u2x was solved by W.Xu, D.Leung, D.Borek, G.Amarasinghe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.12 / 3.15
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	103.925, 103.925, 333.630, 90.00, 90.00, 120.00
R / Rfree (%)	21.5 / 24.9

The binding sites of Chlorine atom in the Ebola Virus VP24 in Complex with Karyopherin Alpha 5 C-Terminus (pdb code 4u2x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Ebola Virus VP24 in Complex with Karyopherin Alpha 5 C-Terminus, PDB code: 4u2x:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Ebola Virus VP24 in Complex with Karyopherin Alpha 5 C-Terminus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ebola Virus VP24 in Complex with Karyopherin Alpha 5 C-Terminus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:60.1 occ:0.50 NH2 A:ARG154 3.4 37.9 1.0 O A:GLY44 3.6 31.0 1.0 O A:HOH401 4.2 42.6 1.0 CZ A:ARG154 4.2 35.5 1.0 NH1 A:ARG154 4.3 34.3 1.0 C A:GLY44 4.7 30.8 1.0 CA A:ILE45 4.8 31.1 1.0 CG1 A:ILE45 5.0 32.1 1.0

Chlorine binding site 2 out of 2 in the Ebola Virus VP24 in Complex with Karyopherin Alpha 5 C-Terminus


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Ebola Virus VP24 in Complex with Karyopherin Alpha 5 C-Terminus within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl301 b:77.7 occ:1.00 OG B:SER70 3.4 91.2 1.0 N B:MET71 3.5 87.3 1.0 N B:THR72 3.7 80.1 1.0 OG1 B:THR72 3.8 75.9 1.0 NH2 A:ARG211 4.1 75.5 1.0 CB B:MET71 4.1 0.1 1.0 CA B:SER70 4.2 75.9 1.0 CA B:MET71 4.2 92.8 1.0 C B:SER70 4.2 76.7 1.0 CB B:SER70 4.2 77.1 1.0 CB B:THR72 4.3 69.5 1.0 C B:MET71 4.5 86.1 1.0 CZ A:ARG211 4.6 72.3 1.0 CA B:THR72 4.7 70.8 1.0 NH1 A:ARG211 4.9 77.9 1.0

W.Xu, M.R.Edwards, D.M.Borek, A.R.Feagins, A.Mittal, J.B.Alinger, K.N.Berry, B.Yen, J.Hamilton, T.J.Brett, R.V.Pappu, D.W.Leung, C.F.Basler, G.K.Amarasinghe. Ebola Virus VP24 Targets A Unique Nls Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1. Cell Host Microbe V. 16 187 2014.
ISSN: ESSN 1934-6069
PubMed: 25121748
DOI: 10.1016/J.CHOM.2014.07.008