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Atomistry » Chlorine » PDB 4u3b-4ufx » 4ub7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4u3b-4ufx » 4ub7 » |
Chlorine in PDB 4ub7: High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen BondEnzymatic activity of High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond
All present enzymatic activity of High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond:
2.7.11.1; Protein crystallography data
The structure of High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond, PDB code: 4ub7
was solved by
K.Niefind,
N.Bischoff,
B.Guerra,
A.Golub,
O.-G.Issinger,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ub7:
The structure of High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond
(pdb code 4ub7). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond, PDB code: 4ub7: Jump to Chlorine binding site number: 1; 2; 3; Chlorine binding site 1 out of 3 in 4ub7Go back to![]() ![]()
Chlorine binding site 1 out
of 3 in the High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 3 in 4ub7Go back to![]() ![]()
Chlorine binding site 2 out
of 3 in the High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond
![]() Mono view ![]() Stereo pair view
Chlorine binding site 3 out of 3 in 4ub7Go back to![]() ![]()
Chlorine binding site 3 out
of 3 in the High-Salt Structure of Protein Kinase CK2 Catalytic Subunit with 4'- Carboxy-6,8-Bromo-Flavonol (FLC26) Showing An Extreme Distortion of the Atp-Binding Loop Combined with A Pi-Halogen Bond
![]() Mono view ![]() Stereo pair view
Reference:
B.Guerra,
N.Bischoff,
V.G.Bdzhola,
S.M.Yarmoluk,
O.G.Issinger,
A.G.Golub,
K.Niefind.
A Note of Caution on the Role of Halogen Bonds For Protein Kinase/Inhibitor Recognition Suggested By High- and Low-Salt CK2 Alpha Complex Structures. Acs Chem.Biol. V. 10 1654 2015.
Page generated: Fri Jul 26 02:09:51 2024
ISSN: ESSN 1554-8937 PubMed: 25961323 DOI: 10.1021/ACSCHEMBIO.5B00235 |
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