Atomistry » Chlorine » PDB 4uij-4uvn » 4usu
Atomistry »
  Chlorine »
    PDB 4uij-4uvn »
      4usu »

Chlorine in PDB 4usu: Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate

Enzymatic activity of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate

All present enzymatic activity of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate:
4.6.1.1;

Protein crystallography data

The structure of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate, PDB code: 4usu was solved by S.Kleinboelting, C.Steegborn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 64.83 / 1.95
Space group P 63
Cell size a, b, c (Å), α, β, γ (°) 100.840, 100.840, 96.770, 90.00, 90.00, 120.00
R / Rfree (%) 15.93 / 21.174

Other elements in 4usu:

The structure of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate (pdb code 4usu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate, PDB code: 4usu:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4usu

Go back to Chlorine Binding Sites List in 4usu
Chlorine binding site 1 out of 2 in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1472

b:32.7
occ:1.00
 O A:HOH2103 3.0 35.1 1.0
NZ A:LYS95 3.1 27.6 1.0
N A:VAL167 3.4 27.9 1.0
CA A:LEU166 3.6 30.6 1.0
CB A:LEU166 3.7 36.3 1.0
CE A:LYS95 3.7 28.2 1.0
CG2 A:VAL167 3.7 28.7 1.0
CD A:LYS95 4.0 31.9 1.0
C A:LEU166 4.0 30.6 1.0
CD2 A:LEU102 4.4 29.3 1.0
CA A:VAL167 4.5 28.4 1.0
CB A:PHE336 4.5 44.0 1.0
CE2 A:PHE165 4.5 29.8 1.0
CB A:VAL167 4.6 27.5 1.0
O A:VAL335 4.6 36.1 1.0
O A:PHE165 4.6 30.1 1.0
O A:VAL167 4.6 30.6 1.0
CA A:PHE336 4.7 39.5 1.0
CB A:LYS95 4.8 26.8 1.0
N A:LEU166 4.9 30.5 1.0
CD2 A:PHE165 5.0 29.9 1.0

Chlorine binding site 2 out of 2 in 4usu

Go back to Chlorine Binding Sites List in 4usu
Chlorine binding site 2 out of 2 in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1473

b:45.2
occ:1.00
 O A:HOH2102 2.8 26.8 1.0
N A:VAL335 3.1 30.0 1.0
O A:VAL335 3.6 36.1 1.0
ND1 A:HIS164 3.6 30.4 1.0
NZ A:LYS95 3.6 27.6 1.0
CA A:LYS334 3.8 34.1 1.0
CE A:LYS95 3.9 28.2 1.0
CD A:LYS334 3.9 48.6 1.0
C A:LYS334 3.9 35.0 1.0
CA A:VAL335 4.0 31.2 1.0
O A:PHE165 4.1 30.1 1.0
CB A:VAL335 4.2 31.4 1.0
C A:VAL335 4.3 36.9 1.0
CG2 A:VAL335 4.3 32.5 1.0
O A:HOH2098 4.4 35.9 1.0
CB A:HIS164 4.4 27.1 1.0
CG A:HIS164 4.5 27.5 1.0
CD A:LYS95 4.5 31.9 1.0
O A:HOH2031 4.5 44.0 1.0
CE1 A:HIS164 4.6 29.9 1.0
CB A:LYS334 4.6 40.0 1.0
CG A:LYS334 4.9 53.0 1.0
CE A:LYS334 4.9 56.4 1.0
N A:PHE165 4.9 27.6 1.0
CA A:HIS164 4.9 25.8 1.0
N A:LYS334 4.9 33.3 1.0
O A:ASN333 4.9 41.5 1.0
O A:HOH2136 5.0 55.7 1.0

Reference:

S.Kleinbolting, J.Van Den Heuvel, C.Steegborn. Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of Its Nucleotide Complexes - Implications For Cyclase Catalysis and Evolution. Febs J. V. 281 4151 2014.
ISSN: ISSN 1742-464X
PubMed: 25040695
DOI: 10.1111/FEBS.12913
Page generated: Fri Jul 11 22:12:54 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy