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Atomistry » Chlorine » PDB 4wcv-4wkq » 4wk7 » |
Chlorine in PDB 4wk7: Crystal Structure of Human Adamts-4 in Complex with Inhibitor (Compound 1, 2-(4-Chlorophenoxy)-N-{[(4R)-4-Methyl-2,5- Dioxoimidazolidin-4-Yl]Methyl} Acetamide)Enzymatic activity of Crystal Structure of Human Adamts-4 in Complex with Inhibitor (Compound 1, 2-(4-Chlorophenoxy)-N-{[(4R)-4-Methyl-2,5- Dioxoimidazolidin-4-Yl]Methyl} Acetamide)
All present enzymatic activity of Crystal Structure of Human Adamts-4 in Complex with Inhibitor (Compound 1, 2-(4-Chlorophenoxy)-N-{[(4R)-4-Methyl-2,5- Dioxoimidazolidin-4-Yl]Methyl} Acetamide):
3.4.24.82; Protein crystallography data
The structure of Crystal Structure of Human Adamts-4 in Complex with Inhibitor (Compound 1, 2-(4-Chlorophenoxy)-N-{[(4R)-4-Methyl-2,5- Dioxoimidazolidin-4-Yl]Methyl} Acetamide), PDB code: 4wk7
was solved by
J.D.Durbin,
S.L.Stout,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4wk7:
The structure of Crystal Structure of Human Adamts-4 in Complex with Inhibitor (Compound 1, 2-(4-Chlorophenoxy)-N-{[(4R)-4-Methyl-2,5- Dioxoimidazolidin-4-Yl]Methyl} Acetamide) also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Adamts-4 in Complex with Inhibitor (Compound 1, 2-(4-Chlorophenoxy)-N-{[(4R)-4-Methyl-2,5- Dioxoimidazolidin-4-Yl]Methyl} Acetamide)
(pdb code 4wk7). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Adamts-4 in Complex with Inhibitor (Compound 1, 2-(4-Chlorophenoxy)-N-{[(4R)-4-Methyl-2,5- Dioxoimidazolidin-4-Yl]Methyl} Acetamide), PDB code: 4wk7: Chlorine binding site 1 out of 1 in 4wk7Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Adamts-4 in Complex with Inhibitor (Compound 1, 2-(4-Chlorophenoxy)-N-{[(4R)-4-Methyl-2,5- Dioxoimidazolidin-4-Yl]Methyl} Acetamide)
![]() Mono view ![]() Stereo pair view
Reference:
T.B.Durham,
V.J.Klimkowski,
C.J.Rito,
J.Marimuthu,
J.L.Toth,
C.Liu,
J.D.Durbin,
S.L.Stout,
L.Adams,
C.Swearingen,
C.Lin,
M.G.Chambers,
K.Thirunavukkarasu,
M.R.Wiley.
Identification of Potent and Selective Hydantoin Inhibitors of Aggrecanase-1 and Aggrecanase-2 That Are Efficacious in Both Chemical and Surgical Models of Osteoarthritis. J.Med.Chem. 2014.
Page generated: Fri Jul 11 22:32:49 2025
ISSN: ISSN 0022-2623 PubMed: 25415648 DOI: 10.1021/JM501522N |
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