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Atomistry » Chlorine » PDB 4wl6-4ws6 » 4wrh » |
Chlorine in PDB 4wrh: AKR1C3 Complexed with Breakdown Product of N-(Tert-Butyl)-2-(2-Chloro- 4-(((3-Mercapto-5-Methyl-4H-1,2,4-Triazol-4-Yl)Amino)Methyl)-6- Methoxyphenoxy)AcetamideEnzymatic activity of AKR1C3 Complexed with Breakdown Product of N-(Tert-Butyl)-2-(2-Chloro- 4-(((3-Mercapto-5-Methyl-4H-1,2,4-Triazol-4-Yl)Amino)Methyl)-6- Methoxyphenoxy)Acetamide
All present enzymatic activity of AKR1C3 Complexed with Breakdown Product of N-(Tert-Butyl)-2-(2-Chloro- 4-(((3-Mercapto-5-Methyl-4H-1,2,4-Triazol-4-Yl)Amino)Methyl)-6- Methoxyphenoxy)Acetamide:
1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.357; 1.1.1.64; Protein crystallography data
The structure of AKR1C3 Complexed with Breakdown Product of N-(Tert-Butyl)-2-(2-Chloro- 4-(((3-Mercapto-5-Methyl-4H-1,2,4-Triazol-4-Yl)Amino)Methyl)-6- Methoxyphenoxy)Acetamide, PDB code: 4wrh
was solved by
C.J.Squire,
J.U.Flanagan,
Y.Yosaatmadja,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the AKR1C3 Complexed with Breakdown Product of N-(Tert-Butyl)-2-(2-Chloro- 4-(((3-Mercapto-5-Methyl-4H-1,2,4-Triazol-4-Yl)Amino)Methyl)-6- Methoxyphenoxy)Acetamide
(pdb code 4wrh). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the AKR1C3 Complexed with Breakdown Product of N-(Tert-Butyl)-2-(2-Chloro- 4-(((3-Mercapto-5-Methyl-4H-1,2,4-Triazol-4-Yl)Amino)Methyl)-6- Methoxyphenoxy)Acetamide, PDB code: 4wrh: Chlorine binding site 1 out of 1 in 4wrhGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the AKR1C3 Complexed with Breakdown Product of N-(Tert-Butyl)-2-(2-Chloro- 4-(((3-Mercapto-5-Methyl-4H-1,2,4-Triazol-4-Yl)Amino)Methyl)-6- Methoxyphenoxy)Acetamide
![]() Mono view ![]() Stereo pair view
Reference:
Y.Yosaatmadja,
R.-W.Ko,
J.U.Flanagan,
C.J.Squire.
Breakdown Product of N-(Tert-Butyl)-2-(2-Chloro-4-(((3-Mercapto-5-Methyl-4H-1,2, 4-Triazol-4-Yl)Amino)Methyl)-6-Methoxyphenoxy)Acetamide Trapped in Active Site of AKR1C3 To Be Published.
Page generated: Fri Jul 11 22:36:47 2025
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