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Atomistry » Chlorine » PDB 4ws7-4wxe » 4wwp » |
Chlorine in PDB 4wwp: Crystal Structure of Human PI3K-Gamma in Complex with Pyridinylquinoline Inhibitor N-{(1S)-1-[8-Chloro-2-(2-Methylpyridin- 3-Yl)Quinolin-3-Yl]Ethyl}-9H-Purin-6-AmineEnzymatic activity of Crystal Structure of Human PI3K-Gamma in Complex with Pyridinylquinoline Inhibitor N-{(1S)-1-[8-Chloro-2-(2-Methylpyridin- 3-Yl)Quinolin-3-Yl]Ethyl}-9H-Purin-6-Amine
All present enzymatic activity of Crystal Structure of Human PI3K-Gamma in Complex with Pyridinylquinoline Inhibitor N-{(1S)-1-[8-Chloro-2-(2-Methylpyridin- 3-Yl)Quinolin-3-Yl]Ethyl}-9H-Purin-6-Amine:
2.7.1.153; 2.7.11.1; Protein crystallography data
The structure of Crystal Structure of Human PI3K-Gamma in Complex with Pyridinylquinoline Inhibitor N-{(1S)-1-[8-Chloro-2-(2-Methylpyridin- 3-Yl)Quinolin-3-Yl]Ethyl}-9H-Purin-6-Amine, PDB code: 4wwp
was solved by
D.A.Whittington,
J.Tang,
P.Yakowec,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human PI3K-Gamma in Complex with Pyridinylquinoline Inhibitor N-{(1S)-1-[8-Chloro-2-(2-Methylpyridin- 3-Yl)Quinolin-3-Yl]Ethyl}-9H-Purin-6-Amine
(pdb code 4wwp). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human PI3K-Gamma in Complex with Pyridinylquinoline Inhibitor N-{(1S)-1-[8-Chloro-2-(2-Methylpyridin- 3-Yl)Quinolin-3-Yl]Ethyl}-9H-Purin-6-Amine, PDB code: 4wwp: Chlorine binding site 1 out of 1 in 4wwpGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human PI3K-Gamma in Complex with Pyridinylquinoline Inhibitor N-{(1S)-1-[8-Chloro-2-(2-Methylpyridin- 3-Yl)Quinolin-3-Yl]Ethyl}-9H-Purin-6-Amine
![]() Mono view ![]() Stereo pair view
Reference:
T.D.Cushing,
X.Hao,
Y.Shin,
K.Andrews,
M.Brown,
M.Cardozo,
Y.Chen,
J.Duquette,
B.Fisher,
F.Gonzalez-Lopez De Turiso,
X.He,
K.R.Henne,
Y.L.Hu,
R.Hungate,
M.G.Johnson,
R.C.Kelly,
B.Lucas,
J.D.Mccarter,
L.R.Mcgee,
J.C.Medina,
T.San Miguel,
D.Mohn,
V.Pattaropong,
L.H.Pettus,
A.Reichelt,
R.M.Rzasa,
J.Seganish,
A.S.Tasker,
R.C.Wahl,
S.Wannberg,
D.A.Whittington,
J.Whoriskey,
G.Yu,
L.Zalameda,
D.Zhang,
D.P.Metz.
Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(Pyridin-2-Yl)Quinolin-3-Yl)Ethyl) -9H-Purin-6-Amine (AMG319) and Related PI3K Delta Inhibitors For Inflammation and Autoimmune Disease. J.Med.Chem. 2014.
Page generated: Fri Jul 11 22:41:16 2025
ISSN: ISSN 0022-2623 PubMed: 25469863 DOI: 10.1021/JM501624R |
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