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Atomistry » Chlorine » PDB 4xpf-4y14 » 4xv9 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4xpf-4y14 » 4xv9 » |
Chlorine in PDB 4xv9: B-Raf Kinase Domain in Complex with PLX5568Enzymatic activity of B-Raf Kinase Domain in Complex with PLX5568
All present enzymatic activity of B-Raf Kinase Domain in Complex with PLX5568:
2.7.11.1; Protein crystallography data
The structure of B-Raf Kinase Domain in Complex with PLX5568, PDB code: 4xv9
was solved by
Y.Zhang,
C.Zhang,
W.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4xv9:
The structure of B-Raf Kinase Domain in Complex with PLX5568 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the B-Raf Kinase Domain in Complex with PLX5568
(pdb code 4xv9). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the B-Raf Kinase Domain in Complex with PLX5568, PDB code: 4xv9: Chlorine binding site 1 out of 1 in 4xv9Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the B-Raf Kinase Domain in Complex with PLX5568
![]() Mono view ![]() Stereo pair view
Reference:
C.Zhang,
W.Spevak,
Y.Zhang,
E.A.Burton,
Y.Ma,
G.Habets,
J.Zhang,
J.Lin,
T.Ewing,
B.Matusow,
G.Tsang,
A.Marimuthu,
H.Cho,
G.Wu,
W.Wang,
D.Fong,
H.Nguyen,
S.Shi,
P.Womack,
M.Nespi,
R.Shellooe,
H.Carias,
B.Powell,
E.Light,
L.Sanftner,
J.Walters,
J.Tsai,
B.L.West,
G.Visor,
H.Rezaei,
P.S.Lin,
K.Nolop,
P.N.Ibrahim,
P.Hirth,
G.Bollag.
Raf Inhibitors That Evade Paradoxical Mapk Pathway Activation. Nature V. 526 583 2015.
Page generated: Fri Jul 26 03:42:12 2024
ISSN: ESSN 1476-4687 PubMed: 26466569 DOI: 10.1038/NATURE14982 |
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