Atomistry » Chlorine » PDB 4ydm-4yl3 » 4yeo
Atomistry »
  Chlorine »
    PDB 4ydm-4yl3 »
      4yeo »

Chlorine in PDB 4yeo: Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement

Enzymatic activity of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement

All present enzymatic activity of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement:
3.2.1.17;

Protein crystallography data

The structure of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement, PDB code: 4yeo was solved by I.G.Shabalin, Z.Dauter, M.Jaskolski, W.Minor, A.Wlodawer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.26 / 0.98
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 26.998, 31.807, 34.072, 89.08, 72.00, 67.81
R / Rfree (%) 11.2 / 13.1

Other elements in 4yeo:

The structure of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement also contains other interesting chemical elements:

Platinum (Pt) 5 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement (pdb code 4yeo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement, PDB code: 4yeo:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4yeo

Go back to Chlorine Binding Sites List in 4yeo
Chlorine binding site 1 out of 2 in the Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl201

b:7.7
occ:0.25
 CL2 A:CPT201 0.0 7.7 0.2
O A:HOH429 2.2 11.0 0.8
PT1 A:CPT201 2.3 5.8 0.2
O A:HOH497 2.9 21.7 1.0
CL1 A:CPT201 3.3 7.6 0.2
NE2 A:HIS15 3.3 18.0 0.6
CD2 A:HIS15 3.8 15.7 0.6
O A:ARG14 4.0 9.6 1.0
CD2 A:HIS15 4.0 15.3 0.4
CE1 A:HIS15 4.0 19.4 0.6
O A:HOH408 4.0 15.9 1.0
O A:HOH430 4.1 10.7 0.8
O A:HOH451 4.1 12.3 0.5
CB A:ARG14 4.1 8.8 1.0
NE2 A:HIS15 4.1 16.8 0.4
N1 A:CPT201 4.3 7.4 0.2
O A:HOH451 4.4 12.0 0.5
CD A:ARG14 4.5 11.2 1.0
C A:ARG14 4.5 7.8 1.0
CG A:HIS15 4.6 15.9 0.6
PT A:PT202 4.7 12.7 0.2
ND1 A:HIS15 4.7 17.6 0.6
CG A:ARG14 4.9 9.8 1.0
NE A:ARG14 4.9 11.6 1.0
CG A:HIS15 5.0 15.3 0.4
CA A:ARG14 5.0 7.7 1.0

Chlorine binding site 2 out of 2 in 4yeo

Go back to Chlorine Binding Sites List in 4yeo
Chlorine binding site 2 out of 2 in the Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl201

b:7.6
occ:0.25
 CL1 A:CPT201 0.0 7.6 0.2
PT1 A:CPT201 2.3 5.8 0.2
O A:HOH429 2.6 11.0 0.8
N1 A:CPT201 3.1 7.4 0.2
CL2 A:CPT201 3.3 7.7 0.2
PT A:PT202 3.3 12.7 0.2
NE A:ARG14 3.7 11.6 1.0
CD A:ARG14 4.0 11.2 1.0
NE2 A:HIS15 4.2 18.0 0.6
O A:HOH451 4.4 12.0 0.5
NE2 A:HIS15 4.6 16.8 0.4
O A:HOH497 4.6 21.7 1.0
CZ A:ARG14 4.7 11.3 1.0
O A:HOH446 4.9 31.2 1.0
NH2 A:ARG14 5.0 13.1 1.0

Reference:

I.G.Shabalin, Z.Dauter, M.Jaskolski, W.Minor, A.Wlodawer. Crystallography and Chemistry Should Always Go Together: A Cautionary Tale of Protein Complexes with Cisplatin and Carboplatin To Be Published.
Page generated: Fri Jul 11 23:20:19 2025

Last articles

Zn in 9UUO
Zn in 9UUS
Zn in 9W4R
Zn in 9VKW
Zn in 9W4S
Zn in 9VH1
Zn in 9RMX
Zn in 9RMU
Zn in 9QWN
Zn in 9U9Y
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy