Atomistry » Chlorine » PDB 5ag4-5ao9 » 5ama
Atomistry »
  Chlorine »
    PDB 5ag4-5ao9 »
      5ama »

Chlorine in PDB 5ama: Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16

Enzymatic activity of Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16

All present enzymatic activity of Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16:
3.4.15.1;

Protein crystallography data

The structure of Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16, PDB code: 5ama was solved by G.Masuyer, K.M.Larmuth, R.G.Douglas, E.D.Sturrock, K.R.Acharya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 113.48 / 1.80
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 73.340, 101.730, 114.140, 85.09, 85.62, 81.30
R / Rfree (%) 18.7 / 21.8

Other elements in 5ama:

The structure of Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16 also contains other interesting chemical elements:

Zinc (Zn) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16 (pdb code 5ama). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16, PDB code: 5ama:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 5ama

Go back to Chlorine Binding Sites List in 5ama
Chlorine binding site 1 out of 4 in the Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1002

b:18.4
occ:1.00
 O A:HOH2201 3.1 20.4 1.0
OH A:TYR202 3.2 20.6 1.0
NE A:ARG500 3.2 17.7 1.0
NH2 A:ARG500 3.5 18.5 1.0
CB A:ARG500 3.6 16.5 1.0
CB A:PRO497 3.7 16.4 1.0
N A:ARG500 3.7 16.0 1.0
CB A:PRO385 3.7 19.6 1.0
CE2 A:TYR202 3.8 21.6 1.0
CZ A:ARG500 3.8 18.0 1.0
CE3 A:TRP201 3.9 24.6 1.0
CG2 A:ILE499 3.9 15.4 1.0
CZ3 A:TRP201 3.9 24.7 1.0
CG A:PRO385 3.9 19.8 1.0
CZ A:TYR202 3.9 21.5 1.0
CG A:ARG500 4.1 16.6 1.0
CA A:ARG500 4.1 16.2 1.0
CD A:ARG500 4.3 17.1 1.0
CG A:PRO497 4.5 16.6 1.0
N A:ILE499 4.7 15.1 1.0
C A:PRO497 4.7 15.8 1.0
CD A:PRO385 4.7 19.7 1.0
C A:ILE499 4.7 15.5 1.0
CA A:PRO497 4.8 16.2 1.0
O A:HOH2343 4.9 18.7 1.0
O A:PRO497 4.9 16.1 1.0
N A:TYR498 5.0 15.3 1.0

Chlorine binding site 2 out of 4 in 5ama

Go back to Chlorine Binding Sites List in 5ama
Chlorine binding site 2 out of 4 in the Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1002

b:16.2
occ:1.00
 OH B:TYR202 3.1 17.2 1.0
O B:HOH2203 3.1 15.2 1.0
NE B:ARG500 3.2 14.2 1.0
NH2 B:ARG500 3.6 15.0 1.0
CB B:ARG500 3.6 13.8 1.0
CB B:PRO497 3.6 14.2 1.0
CB B:PRO385 3.7 14.9 1.0
CE2 B:TYR202 3.7 18.0 1.0
N B:ARG500 3.8 13.9 1.0
CZ B:TYR202 3.8 18.0 1.0
CG B:PRO385 3.9 15.1 1.0
CZ B:ARG500 3.9 14.6 1.0
CE3 B:TRP201 4.0 23.7 1.0
CZ3 B:TRP201 4.0 23.6 1.0
CG2 B:ILE499 4.0 14.4 1.0
CG B:ARG500 4.1 13.8 1.0
CA B:ARG500 4.1 13.8 1.0
CD B:ARG500 4.2 14.1 1.0
CG B:PRO497 4.5 14.2 1.0
C B:PRO497 4.7 13.9 1.0
N B:ILE499 4.7 13.7 1.0
C B:ILE499 4.8 13.9 1.0
CD B:PRO385 4.8 15.2 1.0
CA B:PRO497 4.8 13.8 1.0
O B:HOH2374 4.8 16.6 1.0
O B:PRO497 4.9 13.8 1.0
N B:TYR498 5.0 13.2 1.0

Chlorine binding site 3 out of 4 in 5ama

Go back to Chlorine Binding Sites List in 5ama
Chlorine binding site 3 out of 4 in the Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1002

b:14.9
occ:1.00
 OH C:TYR202 3.1 15.8 1.0
O C:HOH2227 3.1 15.4 1.0
NE C:ARG500 3.2 12.6 1.0
NH2 C:ARG500 3.5 13.0 1.0
CB C:ARG500 3.6 11.9 1.0
N C:ARG500 3.7 11.7 1.0
CB C:PRO385 3.7 13.1 1.0
CB C:PRO497 3.7 13.3 1.0
CE2 C:TYR202 3.7 16.7 1.0
CZ C:TYR202 3.8 16.4 1.0
CG2 C:ILE499 3.8 12.1 1.0
CG C:PRO385 3.9 13.1 1.0
CZ C:ARG500 3.9 12.9 1.0
CE3 C:TRP201 3.9 21.9 1.0
CZ3 C:TRP201 4.0 21.8 1.0
CG C:ARG500 4.0 12.0 1.0
CA C:ARG500 4.1 11.8 1.0
CD C:ARG500 4.2 12.2 1.0
CG C:PRO497 4.6 13.5 1.0
N C:ILE499 4.7 11.9 1.0
CD C:PRO385 4.7 13.2 1.0
C C:ILE499 4.7 11.7 1.0
C C:PRO497 4.8 12.9 1.0
O C:HOH2408 4.8 13.9 1.0
CA C:PRO497 4.9 13.1 1.0
O C:PRO497 5.0 12.8 1.0
N C:TYR498 5.0 12.5 1.0

Chlorine binding site 4 out of 4 in 5ama

Go back to Chlorine Binding Sites List in 5ama
Chlorine binding site 4 out of 4 in the Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Angiotensin-1 Converting Enzyme N-Domain in Complex with Amyloid-Beta 1-16 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1002

b:15.9
occ:1.00
 O D:HOH2187 3.0 17.4 1.0
OH D:TYR202 3.1 15.6 1.0
NE D:ARG500 3.1 13.3 1.0
NH2 D:ARG500 3.5 14.7 1.0
CB D:ARG500 3.6 12.4 1.0
CB D:PRO497 3.7 13.9 1.0
CE2 D:TYR202 3.7 16.3 1.0
N D:ARG500 3.7 12.1 1.0
CB D:PRO385 3.8 15.4 1.0
CZ D:ARG500 3.8 14.2 1.0
CZ D:TYR202 3.8 16.1 1.0
CG D:PRO385 3.8 15.5 1.0
CE3 D:TRP201 3.9 22.8 1.0
CZ3 D:TRP201 3.9 22.7 1.0
CG2 D:ILE499 3.9 12.3 1.0
CG D:ARG500 4.0 12.7 1.0
CA D:ARG500 4.1 12.3 1.0
CD D:ARG500 4.2 13.0 1.0
CG D:PRO497 4.5 14.3 1.0
N D:ILE499 4.7 12.2 1.0
C D:PRO497 4.7 13.4 1.0
C D:ILE499 4.7 12.2 1.0
CD D:PRO385 4.8 15.6 1.0
CA D:PRO497 4.8 13.9 1.0
O D:HOH2365 4.9 15.2 1.0
O D:PRO497 4.9 13.3 1.0
N D:TYR498 5.0 12.6 1.0

Reference:

K.M.Larmuth, G.Masuyer, R.G.Douglas, E.D.Sturrock, K.R.Acharya. The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism By Human Angiotensin-1- Converting Enzyme (Ace) Febs J. V. 283 1060 2016.
ISSN: ISSN 1742-464X
PubMed: 26748546
DOI: 10.1111/FEBS.13647
Page generated: Fri Jul 26 05:19:55 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy