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Atomistry » Chlorine » PDB 5aoa-5b1k » 5arf | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5aoa-5b1k » 5arf » |
Chlorine in PDB 5arf: SMYD2 in Complex with Small Molecule Inhibitor Compound-2Enzymatic activity of SMYD2 in Complex with Small Molecule Inhibitor Compound-2
All present enzymatic activity of SMYD2 in Complex with Small Molecule Inhibitor Compound-2:
2.1.1.43; Protein crystallography data
The structure of SMYD2 in Complex with Small Molecule Inhibitor Compound-2, PDB code: 5arf
was solved by
R.C.Hillig,
V.Badock,
N.Barak,
T.Stellfeld,
E.Eggert,
A.Ter Laak,
J.Weiske,
C.D.Christ,
S.Koehr,
D.Stoeckigt,
J.Mowat,
T.Mueller,
A.E.Fernandez-Montalvan,
I.V.Hartung,
C.Stresemann,
T.Brumby,
H.Weinmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5arf:
The structure of SMYD2 in Complex with Small Molecule Inhibitor Compound-2 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the SMYD2 in Complex with Small Molecule Inhibitor Compound-2
(pdb code 5arf). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the SMYD2 in Complex with Small Molecule Inhibitor Compound-2, PDB code: 5arf: Chlorine binding site 1 out of 1 in 5arfGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the SMYD2 in Complex with Small Molecule Inhibitor Compound-2
![]() Mono view ![]() Stereo pair view
Reference:
E.Eggert,
R.C.Hillig,
S.Kohr,
D.Stockigt,
J.Weiske,
N.Barak,
J.Mowat,
T.Brumby,
C.D.Christ,
A.Ter Laak,
T.Lang,
A.E.Fernandez-Montalvan,
V.Badock,
H.Weinmann,
I.V.Hartung,
D.Barsyte-Lovejoy,
M.Szewczyk,
S.Kennedy,
F.Li,
M.Vedadi,
P.J.Brown,
V.Santhakumar,
C.H.Arrowsmith,
T.Stellfeld,
C.Stresemann.
Discovery and Characterization of A Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (Bay-598) For the Protein Lysine Methyltransferase SMYD2. J.Med.Chem. V. 59 4578 2016.
Page generated: Sat Jul 12 00:19:31 2025
ISSN: ISSN 0022-2623 PubMed: 27075367 DOI: 10.1021/ACS.JMEDCHEM.5B01890 |
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