Chlorine in PDB 5bt5: Crystal Structure of BRD2 Second Bromodomain in Complex with Sgc-CBP30 Chemical Probe

The structure of Crystal Structure of BRD2 Second Bromodomain in Complex with Sgc-CBP30 Chemical Probe, PDB code: 5bt5 was solved by C.Tallant, D.Hay, T.Krojer, G.Nunez-Alonso, S.Picaud, J.A.Newman, O.Fedorov, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, P.E.Brennan, S.Knapp, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.52 / 1.40
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	52.761, 71.806, 31.996, 90.00, 90.00, 90.00
R / Rfree (%)	16 / 18.2

The binding sites of Chlorine atom in the Crystal Structure of BRD2 Second Bromodomain in Complex with Sgc-CBP30 Chemical Probe (pdb code 5bt5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of BRD2 Second Bromodomain in Complex with Sgc-CBP30 Chemical Probe, PDB code: 5bt5:

Chlorine binding site 1 out of 1 in the Crystal Structure of BRD2 Second Bromodomain in Complex with Sgc-CBP30 Chemical Probe


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of BRD2 Second Bromodomain in Complex with Sgc-CBP30 Chemical Probe within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl505 b:65.1 occ:1.00 CL A:2LO505 0.0 65.1 1.0 C16 A:2LO505 1.8 59.2 1.0 C17 A:2LO505 2.8 55.6 1.0 C15 A:2LO505 2.8 58.4 1.0 O A:2LO505 3.0 58.5 1.0 O A:HOH706 3.2 29.6 1.0 C18 A:2LO505 3.3 58.0 1.0 CG A:LYS374 3.8 13.0 1.0 C12 A:2LO505 4.1 50.2 1.0 C14 A:2LO505 4.1 55.6 1.0 O A:HOH717 4.1 40.8 1.0 CB A:LYS374 4.3 10.8 1.0 O A:HOH658 4.4 34.0 1.0 C13 A:2LO505 4.6 53.0 1.0 CD A:LYS374 4.9 15.3 1.0 O A:HOH688 4.9 33.0 1.0 NZ A:LYS374 4.9 19.8 1.0

C.Tallant, D.Hay, T.Krojer, G.Nunez-Alonso, S.Picaud, J.A.Newman, O.Fedorov, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, P.E.Brennan, S.Knapp. Crystal Structure of BRD2 Second Bromodomain in Complex with A 3,5-Dimethylisoxazol Ligand To Be Published.