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Atomistry » Chlorine » PDB 5cb7-5cni » 5cgc | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5cb7-5cni » 5cgc » |
Chlorine in PDB 5cgc: Structure of the Human Class C Gpcr Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator 3-Chloro-4-Fluoro-5-[6-(1H-Pyrazol-1-Yl)Pyrimidin-4- Yl]BenzonitrileEnzymatic activity of Structure of the Human Class C Gpcr Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator 3-Chloro-4-Fluoro-5-[6-(1H-Pyrazol-1-Yl)Pyrimidin-4- Yl]Benzonitrile
All present enzymatic activity of Structure of the Human Class C Gpcr Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator 3-Chloro-4-Fluoro-5-[6-(1H-Pyrazol-1-Yl)Pyrimidin-4- Yl]Benzonitrile:
3.2.1.17; Protein crystallography data
The structure of Structure of the Human Class C Gpcr Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator 3-Chloro-4-Fluoro-5-[6-(1H-Pyrazol-1-Yl)Pyrimidin-4- Yl]Benzonitrile, PDB code: 5cgc
was solved by
J.A.Christopher,
S.J.Aves,
K.A.Bennett,
A.S.Dore,
J.C.Errey,
A.Jazayeri,
F.H.Marshall,
K.Okrasa,
M.J.Serrano-Vega,
B.G.Tehan,
G.R.Wiggin,
M.Congreve,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5cgc:
The structure of Structure of the Human Class C Gpcr Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator 3-Chloro-4-Fluoro-5-[6-(1H-Pyrazol-1-Yl)Pyrimidin-4- Yl]Benzonitrile also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of the Human Class C Gpcr Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator 3-Chloro-4-Fluoro-5-[6-(1H-Pyrazol-1-Yl)Pyrimidin-4- Yl]Benzonitrile
(pdb code 5cgc). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of the Human Class C Gpcr Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator 3-Chloro-4-Fluoro-5-[6-(1H-Pyrazol-1-Yl)Pyrimidin-4- Yl]Benzonitrile, PDB code: 5cgc: Chlorine binding site 1 out of 1 in 5cgcGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Structure of the Human Class C Gpcr Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator 3-Chloro-4-Fluoro-5-[6-(1H-Pyrazol-1-Yl)Pyrimidin-4- Yl]Benzonitrile
![]() Mono view ![]() Stereo pair view
Reference:
J.A.Christopher,
S.J.Aves,
K.A.Bennett,
A.S.Dore,
J.C.Errey,
A.Jazayeri,
F.H.Marshall,
K.Okrasa,
M.J.Serrano-Vega,
B.G.Tehan,
G.R.Wiggin,
M.Congreve.
Fragment and Structure-Based Drug Discovery For A Class C Gpcr: Discovery of the MGLU5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-Fluoropyridin-2-Yl) Pyrimidin-4-Yl]Benzonitrile). J.Med.Chem. V. 58 6653 2015.
Page generated: Fri Jul 26 06:03:30 2024
ISSN: ISSN 0022-2623 PubMed: 26225459 DOI: 10.1021/ACS.JMEDCHEM.5B00892 |
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