Chlorine in PDB 5cls: Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A

Enzymatic activity of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A

All present enzymatic activity of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A:
3.4.11.18;

Protein crystallography data

The structure of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A, PDB code: 5cls was solved by R.Janowski, A.K.Miller, D.Niessing, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	55.82 / 1.75
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	89.620, 101.180, 100.280, 90.00, 90.00, 90.00
*R / R_free (%)*	16 / 18.9

Other elements in 5cls:

The structure of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A also contains other interesting chemical elements:

Cobalt

(Co)

1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A (pdb code 5cls). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A, PDB code: 5cls:

Chlorine binding site 1 out of 1 in 5cls

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Chlorine Binding Sites List in 5cls

Chlorine binding site 1 out of 1 in the Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl508 b:58.6 occ:1.00	N	A:ASP316	2.7	13.5	1.0
	O	A:HOH860	2.8	45.9	1.0
	O	A:HOH786	3.0	37.3	1.0
	O	A:HOH899	3.2	49.5	1.0
	CB	A:LYS272	3.4	15.0	1.0
	CA	A:ASP316	3.6	14.8	1.0
	C	A:ILE315	3.7	12.6	1.0
	CA	A:ILE315	3.8	13.9	1.0
	OD1	A:ASP316	3.8	19.9	1.0
	CD	A:LYS272	4.2	13.6	1.0
	O	A:GLU314	4.2	13.4	1.0
	CG	A:LYS272	4.4	14.7	1.0
	CG	A:ASP316	4.4	16.9	1.0
	CA	A:LYS272	4.4	13.7	1.0
	N	A:ILE315	4.5	13.0	1.0
	N	A:GLY317	4.6	17.8	1.0
	CB	A:ASP316	4.6	15.7	1.0
	O	A:HOH676	4.6	40.3	1.0
	C	A:ASP316	4.6	15.9	1.0
	C	A:GLU314	4.7	13.7	1.0
	O	A:HOH849	4.7	49.7	1.0
	CG2	A:ILE315	4.8	16.7	1.0
	O	A:HOH715	4.8	35.6	1.0
	O	A:ILE315	4.8	13.8	1.0
	CB	A:ILE315	4.9	14.2	1.0
	O	A:HOH752	5.0	53.0	1.0

Reference:

M.Morgen, C.Jost, M.Malz, R.Janowski, D.Niessing, C.D.Klein, N.Gunkel, A.K.Miller. Spiroepoxytriazoles Are Fumagillin-Like Irreversible Inhibitors of METAP2 with Potent Cellular Activity. Acs Chem.Biol. V. 11 1001 2016.
ISSN: ESSN 1554-8937
PubMed: 26686773
DOI: 10.1021/ACSCHEMBIO.5B00755

Page generated: Sat Jul 12 00:49:52 2025

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