Atomistry » Chlorine » PDB 5cu8-5d0x » 5cz9
Atomistry »
  Chlorine »
    PDB 5cu8-5d0x »
      5cz9 »

Chlorine in PDB 5cz9: Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans

Enzymatic activity of Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans

All present enzymatic activity of Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans:
3.4.25.1;

Protein crystallography data

The structure of Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans, PDB code: 5cz9 was solved by E.M.Huber, M.Groll, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 135.720, 300.900, 145.070, 90.00, 112.94, 90.00
R / Rfree (%) 19.9 / 22.3

Other elements in 5cz9:

The structure of Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans also contains other interesting chemical elements:

Magnesium (Mg) 7 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans (pdb code 5cz9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans, PDB code: 5cz9:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 5cz9

Go back to Chlorine Binding Sites List in 5cz9
Chlorine binding site 1 out of 4 in the Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl302

b:34.0
occ:1.00
OH H:TYR69 2.9 38.0 1.0
NH1 G:ARG111 3.0 33.5 1.0
ND2 G:ASN114 3.1 34.2 1.0
CD G:ARG111 3.6 31.4 1.0
CZ H:TYR69 3.7 38.5 1.0
CE2 H:TYR69 3.7 39.2 1.0
CB G:ASN114 3.8 34.2 1.0
CG G:ASN114 3.9 34.2 1.0
CZ G:ARG111 4.1 33.5 1.0
NE G:ARG111 4.3 32.7 1.0
CA G:ARG111 4.6 31.4 1.0
O G:ARG111 4.8 32.9 1.0
O G:HOH422 4.8 33.6 1.0
CG G:ARG111 4.9 30.9 1.0

Chlorine binding site 2 out of 4 in 5cz9

Go back to Chlorine Binding Sites List in 5cz9
Chlorine binding site 2 out of 4 in the Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans within 5.0Å range:
probe atom residue distance (Å) B Occ
N:Cl203

b:53.5
occ:1.00
NH2 N:ARG45 2.9 35.8 1.0
NH1 N:ARG45 3.2 34.9 1.0
NE2 N:GLN53 3.2 31.4 1.0
CZ N:ARG45 3.5 34.5 1.0
CG2 N:THR31 3.6 37.3 1.0
C46 N:3BV201 4.1 37.3 1.0
CB N:ALA49 4.1 32.7 1.0
C45 N:3BV201 4.1 35.5 1.0
CD N:GLN53 4.3 30.3 1.0
OD1 H:ASP120 4.5 73.8 1.0
CG N:GLN53 4.5 29.9 1.0
C44 N:3BV201 4.7 36.3 1.0
CA N:ALA49 4.7 32.2 1.0
O H:THR119 4.7 45.2 1.0
NE N:ARG45 4.8 33.4 1.0
CB a:TYR228 4.8 48.1 1.0
O N:ASP32 4.9 34.7 1.0
OG1 N:THR20 4.9 34.0 1.0
O N:ALA49 5.0 30.5 1.0

Chlorine binding site 3 out of 4 in 5cz9

Go back to Chlorine Binding Sites List in 5cz9
Chlorine binding site 3 out of 4 in the Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans within 5.0Å range:
probe atom residue distance (Å) B Occ
U:Cl301

b:38.0
occ:1.00
OH V:TYR69 3.0 40.6 1.0
NH1 U:ARG111 3.0 43.4 1.0
ND2 U:ASN114 3.1 41.7 1.0
CB U:ASN114 3.6 37.5 1.0
CD U:ARG111 3.7 37.9 1.0
CZ V:TYR69 3.8 42.9 1.0
CE2 V:TYR69 3.8 44.4 1.0
CG U:ASN114 3.8 39.4 1.0
CZ U:ARG111 4.1 42.0 1.0
NE U:ARG111 4.3 40.4 1.0
CA U:ARG111 4.7 36.4 1.0
O U:ARG111 4.8 35.2 1.0

Chlorine binding site 4 out of 4 in 5cz9

Go back to Chlorine Binding Sites List in 5cz9
Chlorine binding site 4 out of 4 in the Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Yeast 20S Proteasome BETA5-D17N Mutant in Complex with Carfilzomib; Propeptide Expressed in Trans within 5.0Å range:
probe atom residue distance (Å) B Occ
b:Cl202

b:49.5
occ:1.00
NE2 b:GLN53 3.0 30.6 1.0
NH2 b:ARG45 3.1 33.0 1.0
NH1 b:ARG45 3.4 33.5 1.0
CZ b:ARG45 3.7 32.3 1.0
CG2 b:THR31 3.7 39.6 1.0
CD b:GLN53 4.1 30.2 1.0
CB b:ALA49 4.2 32.0 1.0
C45 b:3BV201 4.2 36.5 1.0
OD1 V:ASP120 4.2 61.9 1.0
C46 b:3BV201 4.3 37.5 1.0
CG b:GLN53 4.4 30.4 1.0
O V:THR119 4.5 37.2 1.0
CB M:TYR228 4.7 50.8 1.0
CA b:ALA49 4.8 32.2 1.0
C44 b:3BV201 4.8 37.1 1.0
O b:ALA49 5.0 33.0 1.0
OG1 b:THR20 5.0 33.0 1.0
O b:ASP32 5.0 35.9 1.0
NE b:ARG45 5.0 31.6 1.0

Reference:

E.M.Huber, W.Heinemeyer, X.Li, C.S.Arendt, M.Hochstrasser, M.Groll. A Unified Mechanism For Proteolysis and Autocatalytic Activation in the 20S Proteasome. Nat Commun V. 7 10900 2016.
ISSN: ESSN 2041-1723
PubMed: 26964885
DOI: 10.1038/NCOMMS10900
Page generated: Sat Jul 12 01:02:05 2025

Last articles

K in 9FT7
K in 9FQ1
K in 9FM9
K in 9EX3
K in 9F90
K in 9ES6
K in 9EWD
K in 9ETN
K in 9ESI
K in 9ESH
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy