Atomistry » Chlorine » PDB 5d0z-5da3 » 5d2d
Atomistry »
  Chlorine »
    PDB 5d0z-5da3 »
      5d2d »

Chlorine in PDB 5d2d: Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768

Enzymatic activity of Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768

All present enzymatic activity of Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768:
3.6.3.49;

Protein crystallography data

The structure of Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768, PDB code: 5d2d was solved by L.M.Stevers, S.F.R.Leysen, C.Ottmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.09 / 2.10
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 112.862, 112.862, 158.192, 90.00, 90.00, 90.00
R / Rfree (%) 19.3 / 22

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768 (pdb code 5d2d). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768, PDB code: 5d2d:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 5d2d

Go back to Chlorine Binding Sites List in 5d2d
Chlorine binding site 1 out of 4 in the Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl302

b:81.3
occ:0.93
 OE1 A:GLU39 3.0 67.6 1.0
OG A:SER37 3.2 42.0 1.0
OE1 A:GLU40 3.3 53.3 1.0
CG A:GLU40 3.6 46.3 1.0
CD A:GLU40 3.7 50.3 1.0
CD A:GLU39 4.1 62.8 1.0
CB A:GLU39 4.2 43.0 1.0
CB A:SER37 4.3 44.7 1.0
O A:HOH456 4.3 57.1 1.0
CG A:GLU39 4.5 49.0 1.0
N A:GLU40 4.6 38.8 1.0
OE2 A:GLU40 4.6 40.9 1.0
CB A:GLU40 4.8 37.9 1.0

Chlorine binding site 2 out of 4 in 5d2d

Go back to Chlorine Binding Sites List in 5d2d
Chlorine binding site 2 out of 4 in the Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl303

b:73.0
occ:0.92
 OG A:SER28 3.3 51.3 1.0
O A:ALA24 3.7 42.8 1.0
CD2 A:LEU6 4.0 53.4 1.0
C A:ALA24 4.1 43.1 1.0
CA A:CYS25 4.1 40.6 1.0
CB A:SER28 4.1 44.8 1.0
N A:CYS25 4.2 44.1 1.0
O A:HOH454 4.4 49.4 1.0
CB A:ALA24 4.6 40.8 1.0
SG A:CYS25 4.6 47.2 1.0
O A:HOH487 4.9 74.9 1.0
CA A:ALA24 5.0 43.0 1.0
CB A:CYS25 5.0 42.8 1.0

Chlorine binding site 3 out of 4 in 5d2d

Go back to Chlorine Binding Sites List in 5d2d
Chlorine binding site 3 out of 4 in the Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl304

b:85.2
occ:1.00
 CZ A:PHE196 4.0 47.1 1.0
CE2 A:PHE196 4.0 48.4 1.0
NH1 A:ARG222 4.1 43.1 1.0
CD A:ARG222 4.5 39.8 1.0
CG A:GLN219 4.7 59.6 1.0
CB A:MET218 4.8 40.5 1.0
N A:GLN219 4.9 40.9 1.0
CZ A:ARG222 4.9 48.4 1.0
C A:MET218 5.0 40.9 1.0
O A:HOH469 5.0 59.3 1.0

Chlorine binding site 4 out of 4 in 5d2d

Go back to Chlorine Binding Sites List in 5d2d
Chlorine binding site 4 out of 4 in the Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human 14-3-3 Zeta in Complex with Cftr R-Domain Peptide PS753-PS768 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl302

b:80.8
occ:1.00
 OE1 B:GLU39 2.8 75.3 1.0
OG B:SER37 3.3 51.8 1.0
OE2 B:GLU40 3.3 62.6 1.0
CD B:GLU40 3.8 58.3 1.0
CG B:GLU40 3.9 52.6 1.0
CD B:GLU39 4.0 70.2 1.0
CB B:SER37 4.2 47.7 1.0
CB B:GLU39 4.3 53.9 1.0
CG B:GLU39 4.6 65.6 1.0
OE1 B:GLU40 4.8 46.7 1.0
CG1 B:VAL7 4.8 49.3 1.0
N B:GLU40 4.9 43.4 1.0
OE2 B:GLU39 5.0 68.4 1.0

Reference:

L.M.Stevers, C.V.Lam, S.F.Leysen, F.A.Meijer, D.S.Van Scheppingen, R.M.De Vries, G.W.Carlile, L.G.Milroy, D.Y.Thomas, L.Brunsveld, C.Ottmann. Characterization and Small-Molecule Stabilization of the Multisite Tandem Binding Between 14-3-3 and the R Domain of Cftr. Proc.Natl.Acad.Sci.Usa V. 113 E1152 2016.
ISSN: ESSN 1091-6490
PubMed: 26888287
DOI: 10.1073/PNAS.1516631113
Page generated: Sat Jul 12 01:05:19 2025

Last articles

Fe in 2EI2
Fe in 2EI3
Fe in 2EI1
Fe in 2EHA
Fe in 2EI0
Fe in 2EHZ
Fe in 2EFB
Fe in 2E9E
Fe in 2E81
Fe in 2E80
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy