Chlorine in PDB 5f8p: A Novel Inhibitor of the Obesity-Related Protein Fto

The structure of A Novel Inhibitor of the Obesity-Related Protein Fto, PDB code: 5f8p was solved by J.Chai, B.Zhou, W.Liu, Z.Han, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.87 / 2.20
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	142.218, 142.218, 83.028, 90.00, 90.00, 120.00
R / Rfree (%)	18.8 / 23.4

The structure of A Novel Inhibitor of the Obesity-Related Protein Fto also contains other interesting chemical elements:

Iron

(Fe)

1 atom

The binding sites of Chlorine atom in the A Novel Inhibitor of the Obesity-Related Protein Fto (pdb code 5f8p). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the A Novel Inhibitor of the Obesity-Related Protein Fto, PDB code: 5f8p:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the A Novel Inhibitor of the Obesity-Related Protein Fto


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A Novel Inhibitor of the Obesity-Related Protein Fto within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:70.7 occ:1.00 CL1 A:FIJ602 0.0 70.7 1.0 C05 A:FIJ602 1.7 65.4 1.0 C06 A:FIJ602 2.7 60.3 1.0 C04 A:FIJ602 2.7 64.3 1.0 O02 A:FIJ602 3.0 67.5 1.0 CB A:LEU90 3.6 44.8 1.0 CG2 A:THR92 3.7 47.6 1.0 CG2 A:VAL83 3.7 57.9 1.0 CA A:THR92 4.0 53.0 1.0 C03 A:FIJ602 4.0 63.3 1.0 CD1 A:ILE85 4.0 58.2 1.0 CD1 A:LEU90 4.0 51.5 1.0 C01 A:FIJ602 4.0 67.4 1.0 N A:THR92 4.2 42.3 1.0 O A:LEU90 4.2 50.1 1.0 CD1 A:LEU109 4.3 57.5 1.0 CB A:THR92 4.4 53.3 1.0 C A:LEU90 4.4 56.2 1.0 CG A:LEU90 4.5 53.4 1.0 C A:LEU91 4.5 52.1 1.0 C02 A:FIJ602 4.6 66.0 1.0 CA A:LEU90 4.7 50.3 1.0 CD A:PRO93 4.7 60.5 1.0 O A:LEU91 4.8 60.8 1.0 N A:LEU91 4.9 51.1 1.0

Chlorine binding site 2 out of 2 in the A Novel Inhibitor of the Obesity-Related Protein Fto


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of A Novel Inhibitor of the Obesity-Related Protein Fto within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:81.2 occ:1.00 CL A:FIJ602 0.0 81.2 1.0 C17 A:FIJ602 1.7 73.0 1.0 C16 A:FIJ602 2.7 70.3 1.0 C A:FIJ602 2.7 68.1 1.0 O03 A:FIJ602 3.0 61.4 1.0 CE1 A:TYR108 3.2 71.3 1.0 OH A:TYR108 3.2 74.7 1.0 CZ A:TYR108 3.2 73.8 1.0 O A:HOH768 3.5 48.9 1.0 CD2 A:HIS231 3.7 45.2 1.0 CD2 A:LEU109 3.9 50.8 1.0 C10 A:FIJ602 4.0 67.7 1.0 C15 A:FIJ602 4.0 72.5 1.0 CD1 A:TYR108 4.0 69.7 1.0 NE2 A:HIS231 4.1 44.1 1.0 O A:HOH704 4.1 63.2 1.0 CE2 A:TYR108 4.1 73.2 1.0 CG A:LEU109 4.2 55.3 1.0 CG A:HIS231 4.3 41.9 1.0 C11 A:FIJ602 4.5 70.8 1.0 CD1 A:LEU109 4.6 57.5 1.0 O1 A:AKG603 4.6 78.6 1.0 CG A:TYR108 4.7 66.7 1.0 CD2 A:TYR108 4.7 67.6 1.0 CE1 A:HIS231 4.8 43.1 1.0 ND1 A:HIS231 4.9 49.1 1.0 CB A:HIS231 5.0 36.5 1.0

J.Chai, B.Zhou, W.Liu, Z.Han. Crystal Structure of Fto-Chtb To Be Published.