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Atomistry » Chlorine » PDB 5h6g-5hi5 » 5hi2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5h6g-5hi5 » 5hi2 » |
Chlorine in PDB 5hi2: Braf Kinase Domain B3AC Loop Deletion Mutant in Complex with SorafenibEnzymatic activity of Braf Kinase Domain B3AC Loop Deletion Mutant in Complex with Sorafenib
All present enzymatic activity of Braf Kinase Domain B3AC Loop Deletion Mutant in Complex with Sorafenib:
2.7.11.1; Protein crystallography data
The structure of Braf Kinase Domain B3AC Loop Deletion Mutant in Complex with Sorafenib, PDB code: 5hi2
was solved by
D.M.Whalen,
S.A.Foster,
A.Ozen,
M.Wongchenko,
J.Yin,
G.Schaefer,
J.Mayfield,
J.Chmielecki,
P.Stephens,
L.Albacker,
Y.Yan,
K.Song,
G.Hatzivassiliou,
C.Eigenbrot,
C.Yu,
A.S.Shaw,
G.Manning,
N.J.Skelton,
S.G.Hymowitz,
S.Malek,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5hi2:
The structure of Braf Kinase Domain B3AC Loop Deletion Mutant in Complex with Sorafenib also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Braf Kinase Domain B3AC Loop Deletion Mutant in Complex with Sorafenib
(pdb code 5hi2). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Braf Kinase Domain B3AC Loop Deletion Mutant in Complex with Sorafenib, PDB code: 5hi2: Chlorine binding site 1 out of 1 in 5hi2Go back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Braf Kinase Domain B3AC Loop Deletion Mutant in Complex with Sorafenib
![]() Mono view ![]() Stereo pair view
Reference:
S.A.Foster,
D.M.Whalen,
A.Ozen,
M.J.Wongchenko,
J.Yin,
I.Yen,
G.Schaefer,
J.D.Mayfield,
J.Chmielecki,
P.J.Stephens,
L.A.Albacker,
Y.Yan,
K.Song,
G.Hatzivassiliou,
C.Eigenbrot,
C.Yu,
A.S.Shaw,
G.Manning,
N.J.Skelton,
S.G.Hymowitz,
S.Malek.
Activation Mechanism of Oncogenic Deletion Mutations in Braf, Egfr, and HER2. Cancer Cell V. 29 477 2016.
Page generated: Sat Jul 12 02:46:07 2025
ISSN: ISSN 1535-6108 PubMed: 26996308 DOI: 10.1016/J.CCELL.2016.02.010 |
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