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Atomistry » Chlorine » PDB 5i1t-5ibn » 5i8a | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5i1t-5ibn » 5i8a » |
Chlorine in PDB 5i8a: Trka with (6~{R})-3-Methylsulfanyl-6-Phenyl-1-(1~{H}-Pyrazol-3-Yl)-6, 7-Dihydro-5~{H}-Thieno[3,4-C]Pyridin-4-OneEnzymatic activity of Trka with (6~{R})-3-Methylsulfanyl-6-Phenyl-1-(1~{H}-Pyrazol-3-Yl)-6, 7-Dihydro-5~{H}-Thieno[3,4-C]Pyridin-4-One
All present enzymatic activity of Trka with (6~{R})-3-Methylsulfanyl-6-Phenyl-1-(1~{H}-Pyrazol-3-Yl)-6, 7-Dihydro-5~{H}-Thieno[3,4-C]Pyridin-4-One:
2.7.10.1; Protein crystallography data
The structure of Trka with (6~{R})-3-Methylsulfanyl-6-Phenyl-1-(1~{H}-Pyrazol-3-Yl)-6, 7-Dihydro-5~{H}-Thieno[3,4-C]Pyridin-4-One, PDB code: 5i8a
was solved by
H.P.Su,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Trka with (6~{R})-3-Methylsulfanyl-6-Phenyl-1-(1~{H}-Pyrazol-3-Yl)-6, 7-Dihydro-5~{H}-Thieno[3,4-C]Pyridin-4-One
(pdb code 5i8a). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trka with (6~{R})-3-Methylsulfanyl-6-Phenyl-1-(1~{H}-Pyrazol-3-Yl)-6, 7-Dihydro-5~{H}-Thieno[3,4-C]Pyridin-4-One, PDB code: 5i8a: Chlorine binding site 1 out of 1 in 5i8aGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Trka with (6~{R})-3-Methylsulfanyl-6-Phenyl-1-(1~{H}-Pyrazol-3-Yl)-6, 7-Dihydro-5~{H}-Thieno[3,4-C]Pyridin-4-One
![]() Mono view ![]() Stereo pair view
Reference:
T.J.Greshock,
J.M.Sanders,
R.E.Drolet,
H.A.Rajapakse,
R.K.Chang,
B.Kim,
V.L.Rada,
H.E.Tiscia,
H.Su,
M.T.Lai,
S.M.Sur,
R.I.Sanchez,
M.T.Bilodeau,
J.J.Renger,
J.T.Kern,
J.A.Mccauley.
Potent, Selective and Orally Bioavailable Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors. Bioorg. Med. Chem. Lett. V. 26 2631 2016.
Page generated: Fri Jul 26 09:13:02 2024
ISSN: ESSN 1464-3405 PubMed: 27106707 DOI: 10.1016/J.BMCL.2016.04.021 |
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