Atomistry » Chlorine » PDB 5jkd-5jsv » 5jsv
Atomistry »
  Chlorine »
    PDB 5jkd-5jsv »
      5jsv »

Chlorine in PDB 5jsv: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One, PDB code: 5jsv was solved by F.R.Ehrmann, D.Nguyen, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.95 / 1.17
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.505, 65.200, 70.598, 90.00, 96.44, 90.00
R / Rfree (%) 12.1 / 13.9

Other elements in 5jsv:

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One (pdb code 5jsv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One, PDB code: 5jsv:

Chlorine binding site 1 out of 1 in 5jsv

Go back to Chlorine Binding Sites List in 5jsv
Chlorine binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AR,4R,6R,6AR)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4- D][1,3]Dioxol-4-Yl)Methyl)Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)- One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl405

b:14.2
occ:1.00
 O A:HOH718 2.9 42.7 1.0
OG1 A:THR285 3.0 11.2 1.0
O A:HOH578 3.2 14.2 1.0
NH1 A:ARG289 3.3 13.2 1.0
O A:HOH564 3.4 20.0 0.5
CB A:THR285 3.6 11.2 1.0
N A:ARG286 3.7 11.4 0.3
N A:ARG286 3.7 10.9 0.7
NH2 A:ARG289 3.8 16.2 1.0
CB A:ARG286 4.0 13.6 0.7
CB A:VAL282 4.0 13.1 1.0
CB A:ARG286 4.0 13.3 0.3
O A:HOH791 4.0 23.6 1.0
CZ A:ARG289 4.0 14.4 1.0
CD A:LYS52 4.1 14.6 1.0
CA A:ARG286 4.1 12.3 0.3
CA A:ARG286 4.1 11.9 0.7
CG1 A:VAL282 4.2 14.6 1.0
O A:VAL282 4.2 11.8 1.0
CE A:LYS52 4.3 16.0 1.0
C A:THR285 4.3 11.0 1.0
CG A:LYS52 4.5 11.9 1.0
CA A:THR285 4.5 10.8 1.0
CA A:VAL282 4.5 11.4 1.0
NE A:ARG286 4.7 16.8 0.3
CG2 A:THR285 4.7 12.3 1.0
CB A:LYS52 4.8 11.4 1.0
C A:VAL282 4.9 11.1 1.0
CG A:ARG286 4.9 15.5 0.7
CG A:ARG286 5.0 14.4 0.3

Reference:

F.R.Ehrmann, E.Schaefer, A.Heine, F.Diederich, G.Klebe. Application of Carbohydrates Based Lin-Benzoguanines in A Solvent-Exposed Subpocket of the Trna-Modifying Enzyme Tgt To Be Published.
Page generated: Sat Jul 12 03:44:56 2025

Last articles

Fe in 2OYE
Fe in 2OYU
Fe in 2OWT
Fe in 2OWJ
Fe in 2OWS
Fe in 2OWH
Fe in 2ORT
Fe in 2ORS
Fe in 2ORR
Fe in 2ORL
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy