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Atomistry » Chlorine » PDB 5jsw-5jzn » 5jsw » |
Chlorine in PDB 5jsw: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-OneEnzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One:
2.4.2.29; Protein crystallography data
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 5jsw
was solved by
F.R.Ehrmann,
D.Nguyen,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5jsw:
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
(pdb code 5jsw). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 5jsw: Chlorine binding site 1 out of 1 in 5jswGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
![]() Mono view ![]() Stereo pair view
Reference:
F.R.Ehrmann,
E.Schaefer,
A.Heine,
F.Diederich,
G.Klebe.
Application of Carbohydrates Based Lin-Benzoguanines in A Solvent-Exposed Subpocket of the Trna-Modifying Enzyme Tgt To Be Published.
Page generated: Fri Jul 26 10:15:05 2024
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