Atomistry » Chlorine » PDB 5l7i-5lf1 » 5lbb
Atomistry »
  Chlorine »
    PDB 5l7i-5lf1 »
      5lbb »

Chlorine in PDB 5lbb: Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9)

Enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9)

All present enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9):
1.14.11.29;

Protein crystallography data

The structure of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9), PDB code: 5lbb was solved by R.Chowdhury, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.07 / 1.70
Space group P 63
Cell size a, b, c (Å), α, β, γ (°) 110.199, 110.199, 39.717, 90.00, 90.00, 120.00
R / Rfree (%) 15.2 / 17.8

Other elements in 5lbb:

The structure of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9) also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9) (pdb code 5lbb). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9), PDB code: 5lbb:

Chlorine binding site 1 out of 1 in 5lbb

Go back to Chlorine Binding Sites List in 5lbb
Chlorine binding site 1 out of 1 in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R396T Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl502

b:28.1
occ:1.00
CL1 A:UN9502 0.0 28.1 1.0
C7 A:UN9502 1.8 24.1 1.0
N8 A:UN9502 2.6 25.2 1.0
H1 A:UN9502 2.8 37.2 1.0
C2 A:UN9502 2.8 24.1 1.0
C1 A:UN9502 3.1 31.0 1.0
HZ2 A:TRP389 3.3 31.2 1.0
O A:HOH640 3.4 47.4 1.0
OD1 A:ASP315 3.4 21.7 1.0
MN A:MN501 3.4 23.4 1.0
HD2 A:HIS313 3.5 28.5 1.0
NE2 A:HIS313 3.5 20.2 1.0
CD2 A:HIS313 3.7 23.8 1.0
O A:HOH609 3.8 41.6 1.0
O A:HOH716 3.9 47.4 1.0
C9 A:UN9502 3.9 21.5 1.0
HH A:TYR310 3.9 34.9 1.0
HA A:ASP315 3.9 29.5 1.0
OH A:TYR310 4.1 29.1 1.0
C3 A:UN9502 4.1 24.5 1.0
CZ2 A:TRP389 4.1 26.0 1.0
CG A:ASP315 4.2 25.9 1.0
O A:HOH641 4.3 23.9 1.0
HH2 A:TRP389 4.3 30.6 1.0
C10 A:UN9502 4.5 26.6 1.0
CZ A:TYR310 4.5 29.6 1.0
C6 A:UN9502 4.5 31.2 1.0
HE1 A:TYR310 4.6 36.9 1.0
CE1 A:HIS313 4.6 24.7 1.0
CH2 A:TRP389 4.6 25.5 1.0
HH12 A:ARG322 4.7 42.0 1.0
CE1 A:TYR310 4.7 30.7 1.0
CA A:ASP315 4.8 24.6 1.0
HE1 A:MET299 4.8 36.0 1.0
C12 A:UN9502 4.8 22.7 1.0
CG A:HIS313 4.9 23.5 1.0
OD2 A:ASP315 4.9 23.5 1.0
CB A:ASP315 4.9 22.6 1.0
HB3 A:ASP315 4.9 27.1 1.0
O13 A:UN9502 4.9 23.2 1.0
H6 A:UN9502 5.0 37.5 1.0

Reference:

R.Chowdhury, I.K.Leung, Y.M.Tian, M.I.Abboud, W.Ge, C.Domene, F.X.Cantrelle, I.Landrieu, A.P.Hardy, C.W.Pugh, P.J.Ratcliffe, T.D.Claridge, C.J.Schofield. Structural Basis For Oxygen Degradation Domain Selectivity of the Hif Prolyl Hydroxylases. Nat Commun V. 7 12673 2016.
ISSN: ESSN 2041-1723
PubMed: 27561929
DOI: 10.1038/NCOMMS12673
Page generated: Sat Jul 12 04:30:18 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy