Chlorine in PDB 5lv0: Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product

All present enzymatic activity of Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product:
3.4.24.16;

The structure of Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product, PDB code: 5lv0 was solved by G.Masuyer, R.P.-A.Berntsson, P.F.Teixeira, B.Kmiec, E.Glaser, P.Stenmark, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	109.11 / 2.70
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	131.341, 131.341, 195.979, 90.00, 90.00, 90.00
R / Rfree (%)	21 / 26

The structure of Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product (pdb code 5lv0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product, PDB code: 5lv0:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl702 b:56.9 occ:1.00 ND2 A:ASN163 3.2 52.7 1.0 CD1 B:PHE109 3.8 50.1 1.0 CA A:GLN160 3.9 55.4 1.0 CB B:GLU112 3.9 48.3 1.0 CG B:GLU112 3.9 48.0 1.0 CB A:GLN160 4.0 55.8 1.0 CE B:MET113 4.0 50.6 1.0 CE1 B:PHE109 4.2 50.9 1.0 CE B:LYS46 4.3 62.7 1.0 CG A:ASN163 4.4 52.5 1.0 CD B:LYS46 4.5 62.4 1.0 N A:GLN160 4.6 55.5 1.0 CB A:ASN163 4.6 52.6 1.0 NH2 B:ARG105 4.7 47.9 1.0 CD B:GLU112 4.8 47.9 1.0 O A:GLU159 4.8 55.0 1.0 O A:GLN160 4.9 55.0 1.0 CG B:PHE109 4.9 49.2 1.0 C A:GLN160 5.0 54.8 1.0 C A:GLU159 5.0 55.8 1.0 CA B:PHE109 5.0 48.7 1.0

Chlorine binding site 2 out of 2 in the Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human Neurolysin (E475Q) in Complex with Amyloid-Beta 35- 40 Peptide Product within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl702 b:57.4 occ:1.00 ND2 B:ASN163 3.3 52.2 1.0 CA B:GLN160 3.7 58.8 1.0 CB B:GLN160 3.8 59.8 1.0 CD1 A:PHE109 3.8 54.2 1.0 CB A:GLU112 3.9 55.4 1.0 CG A:GLU112 4.0 55.1 1.0 CE A:MET113 4.2 58.7 1.0 CE1 A:PHE109 4.2 54.4 1.0 CG B:ASN163 4.3 52.1 1.0 CE A:LYS46 4.4 65.3 1.0 CB B:ASN163 4.4 52.5 1.0 CD A:LYS46 4.4 65.2 1.0 N B:GLN160 4.5 59.3 1.0 NH2 A:ARG105 4.6 51.8 1.0 O B:GLN160 4.7 58.8 1.0 C B:GLN160 4.8 58.2 1.0 O B:GLU159 4.8 58.8 1.0 CD A:GLU112 4.8 55.3 1.0 CG2 A:ILE42 4.9 59.9 1.0 C B:GLU159 4.9 59.4 1.0 CG A:PHE109 5.0 53.7 1.0 CA A:PHE109 5.0 52.6 1.0

P.F.Teixeira, G.Masuyer, C.Pinho, R.M.M.Branca, B.Kmiec, C.Wallin, S.Warmlander, R.P.-A.Berntsson, M.Ankarcrona, A.Graslund, J.Lehtio, P.Stenmark, E.Glaser. Structural and Functional Analysis of Neurolysin, A New Component of the Mitochondrial Peptidolytic Network To Be Published.