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Chlorine in PDB 5mjn: Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide
Enzymatic activity of Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide
All present enzymatic activity of Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide, PDB code: 5mjn
was solved by
J.Leitans,
K.Tars,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 18.00 / 1.17 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.360, 41.320, 72.250, 90.00, 104.48, 90.00 |
| R / Rfree (%) | 14 / 17.3 |
Other elements in 5mjn:
The structure of Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide
(pdb code 5mjn). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide, PDB code: 5mjn:
In total only one binding site of Chlorine was determined in the Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide, PDB code: 5mjn:
Chlorine binding site 1 out of 1 in 5mjn
Go back to
Chlorine Binding Sites List in 5mjn
Chlorine binding site 1 out
of 1 in the Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Three Dimensional Structure of Human Carbonic Anhydrase II in Complex with 5-[(4CHLOROBENZYL)Sulfanyl]Thiophene-2-Sulfonamide within 5.0Å range:
|
Reference:
J.Ivanova,
A.Balode,
R.Zalubovskis,
J.Leitans,
A.Kazaks,
D.Vullo,
K.Tars,
C.T.Supuran.
5-Substituted-Benzylsulfanyl-Thiophene-2-Sulfonamides with Effective Carbonic Anhydrase Inhibitory Activity: Solution and Crystallographic Investigations. Bioorg. Med. Chem. V. 25 857 2017.
ISSN: ESSN 1464-3391
PubMed: 28024887
DOI: 10.1016/J.BMC.2016.11.045
Page generated: Sat Jul 12 05:31:10 2025
ISSN: ESSN 1464-3391
PubMed: 28024887
DOI: 10.1016/J.BMC.2016.11.045
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