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Chlorine in PDB 5n9l: Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B)
Enzymatic activity of Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B)
All present enzymatic activity of Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B):
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B), PDB code: 5n9l
was solved by
A.Schnitzler,
A.Gratz,
A.Bollacke,
M.Weyrich,
U.Kucklaender,
B.Wuensch,
C.Goetz,
K.Niefind,
J.Jose,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 36.14 / 1.79 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 57.437, 45.706, 63.187, 90.00, 110.94, 90.00 |
| R / Rfree (%) | 16.4 / 19.9 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B)
(pdb code 5n9l). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B), PDB code: 5n9l:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B), PDB code: 5n9l:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 5n9l
Go back to
Chlorine Binding Sites List in 5n9l
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B) within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 5n9l
Go back to
Chlorine Binding Sites List in 5n9l
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Human Protein Kinase CK2 Catalytic Subunit in Complex with the Atp-Competitive Dibenzofuran Inhibitor Tf (4B) within 5.0Å range:
|
Reference:
A.Schnitzler,
A.Gratz,
A.Bollacke,
M.Weyrich,
U.Kucklander,
B.Wunsch,
C.Gotz,
K.Niefind,
J.Jose.
A Pi-Halogen Bond of Dibenzofuranones with the Gatekeeper PHE113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors. Pharmaceuticals V. 11 2018.
ISSN: ESSN 1424-8247
PubMed: 29462988
DOI: 10.3390/PH11010023
Page generated: Sat Jul 12 05:56:14 2025
ISSN: ESSN 1424-8247
PubMed: 29462988
DOI: 10.3390/PH11010023
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