Chlorine in PDB 5o14: Co-Crystal Structure of A Cross-Reactive Bactericidal Human Antibody Targeting Meningococcal Vaccine Antigen Factor H Binding Protein

The structure of Co-Crystal Structure of A Cross-Reactive Bactericidal Human Antibody Targeting Meningococcal Vaccine Antigen Factor H Binding Protein, PDB code: 5o14 was solved by J.Lopez-Sagaseta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.91 / 2.20
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.822, 163.951, 110.656, 90.00, 97.70, 90.00
R / Rfree (%)	19.2 / 25

The binding sites of Chlorine atom in the Co-Crystal Structure of A Cross-Reactive Bactericidal Human Antibody Targeting Meningococcal Vaccine Antigen Factor H Binding Protein (pdb code 5o14). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Co-Crystal Structure of A Cross-Reactive Bactericidal Human Antibody Targeting Meningococcal Vaccine Antigen Factor H Binding Protein, PDB code: 5o14:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Co-Crystal Structure of A Cross-Reactive Bactericidal Human Antibody Targeting Meningococcal Vaccine Antigen Factor H Binding Protein


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Co-Crystal Structure of A Cross-Reactive Bactericidal Human Antibody Targeting Meningococcal Vaccine Antigen Factor H Binding Protein within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl301 b:30.2 occ:1.00 N D:PHE99 3.1 23.2 1.0 N C:TRP47 3.4 15.5 1.0 CA D:THR98 3.6 22.1 1.0 CB D:THR98 3.6 24.8 1.0 O C:HOH475 3.7 41.7 1.0 CD1 D:PHE99 3.8 19.9 1.0 C D:THR98 3.8 21.4 1.0 CA C:GLU46 4.0 27.2 1.0 CB C:TRP47 4.0 17.0 1.0 O C:LEU45 4.0 15.6 1.0 CA D:PHE99 4.1 20.0 1.0 CG2 D:THR98 4.1 26.3 1.0 CB D:PHE99 4.1 15.3 1.0 C C:GLU46 4.2 24.4 1.0 O D:PHE99 4.2 17.6 1.0 CA C:TRP47 4.3 17.6 1.0 CG D:PHE99 4.4 17.7 1.0 CG C:GLU46 4.5 37.3 1.0 C D:PHE99 4.6 20.6 1.0 C C:LEU45 4.8 15.7 1.0 CB C:GLU46 4.8 31.3 1.0 N C:GLU46 4.8 28.1 1.0 CE1 D:PHE99 4.8 20.5 1.0 N D:THR98 4.9 22.0 1.0 OG1 D:THR98 4.9 26.2 1.0 O C:TRP47 5.0 20.6 1.0

Chlorine binding site 2 out of 2 in the Co-Crystal Structure of A Cross-Reactive Bactericidal Human Antibody Targeting Meningococcal Vaccine Antigen Factor H Binding Protein


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Co-Crystal Structure of A Cross-Reactive Bactericidal Human Antibody Targeting Meningococcal Vaccine Antigen Factor H Binding Protein within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl301 b:34.7 occ:1.00 N L:PHE99 3.2 24.9 1.0 N H:TRP47 3.2 25.9 1.0 CA L:THR98 3.6 23.4 1.0 CB L:THR98 3.7 28.1 1.0 CB H:TRP47 3.8 24.4 1.0 CD1 L:PHE99 3.8 21.2 1.0 C L:THR98 3.9 24.9 1.0 CA H:GLU46 3.9 28.8 1.0 O H:LEU45 4.0 25.7 1.0 C H:GLU46 4.1 29.5 1.0 CA H:TRP47 4.1 26.4 1.0 CG2 L:THR98 4.1 27.3 1.0 CA L:PHE99 4.2 22.9 1.0 CB L:PHE99 4.2 20.6 1.0 O L:PHE99 4.3 26.9 1.0 CG L:PHE99 4.5 24.9 1.0 CG H:GLU46 4.5 41.9 1.0 O H:TRP47 4.7 28.8 1.0 C L:PHE99 4.7 25.2 1.0 CE1 L:PHE99 4.8 21.7 1.0 C H:LEU45 4.8 23.9 1.0 CB H:GLU46 4.8 36.1 1.0 N H:GLU46 4.8 24.0 1.0 N L:THR98 4.8 23.9 1.0 C H:TRP47 4.9 27.8 1.0 OG1 L:THR98 5.0 30.5 1.0 O L:TYR97 5.0 27.6 1.0

J.Lopez-Sagaseta, P.T.Beernink, F.Bianchi, L.Santini, E.Frigimelica, A.H.Lucas, M.Pizza, M.J.Bottomley. Crystal Structure Reveals Vaccine Elicited Bactericidal Human Antibody Targeting A Conserved Epitope on Meningococcal Fhbp. Nat Commun V. 9 528 2018.
ISSN: ESSN 2041-1723
PubMed: 29410413
DOI: 10.1038/S41467-018-02827-7