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Atomistry » Chlorine » PDB 5ona-5os5 » 5opu | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5ona-5os5 » 5opu » |
Chlorine in PDB 5opu: Structure of CHK1 10-Pt. Mutant Complex with Pyrrolopyridine LRRK2 InhibitorEnzymatic activity of Structure of CHK1 10-Pt. Mutant Complex with Pyrrolopyridine LRRK2 Inhibitor
All present enzymatic activity of Structure of CHK1 10-Pt. Mutant Complex with Pyrrolopyridine LRRK2 Inhibitor:
2.7.11.1; Protein crystallography data
The structure of Structure of CHK1 10-Pt. Mutant Complex with Pyrrolopyridine LRRK2 Inhibitor, PDB code: 5opu
was solved by
P.Dokurno,
D.S.Williamson,
P.Acheson-Dossang,
I.Chen,
J.B.Murray,
T.Shaw,
A.E.Surgenor,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of CHK1 10-Pt. Mutant Complex with Pyrrolopyridine LRRK2 Inhibitor
(pdb code 5opu). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of CHK1 10-Pt. Mutant Complex with Pyrrolopyridine LRRK2 Inhibitor, PDB code: 5opu: Chlorine binding site 1 out of 1 in 5opuGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Structure of CHK1 10-Pt. Mutant Complex with Pyrrolopyridine LRRK2 Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
D.S.Williamson,
G.P.Smith,
P.Acheson-Dossang,
S.T.Bedford,
V.Chell,
I.J.Chen,
J.C.A.Daechsel,
Z.Daniels,
L.David,
P.Dokurno,
M.Hentzer,
M.C.Herzig,
R.E.Hubbard,
J.D.Moore,
J.B.Murray,
S.Newland,
S.C.Ray,
T.Shaw,
A.E.Surgenor,
L.Terry,
K.Thirstrup,
Y.Wang,
K.V.Christensen.
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using A Crystallographic Surrogate Derived From Checkpoint Kinase 1 (CHK1). J. Med. Chem. V. 60 8945 2017.
Page generated: Sat Jul 12 06:52:57 2025
ISSN: ISSN 1520-4804 PubMed: 29023112 DOI: 10.1021/ACS.JMEDCHEM.7B01186 |
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