Chlorine »
PDB 5ona-5os5 »
5os5 »
Chlorine in PDB 5os5: Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment
Enzymatic activity of Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment
All present enzymatic activity of Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment, PDB code: 5os5
was solved by
P.J.Mcintyre,
P.M.Collins,
F.Von Delft,
R.Bayliss,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 66.07 / 1.74 |
| Space group | P 61 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 82.370, 82.370, 175.310, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 19.7 / 23.6 |
Other elements in 5os5:
The structure of Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment also contains other interesting chemical elements:
| Magnesium | (Mg) | 2 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment
(pdb code 5os5). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment, PDB code: 5os5:
Jump to Chlorine binding site number: 1; 2; 3;
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment, PDB code: 5os5:
Jump to Chlorine binding site number: 1; 2; 3;
Chlorine binding site 1 out of 3 in 5os5
Go back to
Chlorine Binding Sites List in 5os5
Chlorine binding site 1 out
of 3 in the Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment within 5.0Å range:
|
Chlorine binding site 2 out of 3 in 5os5
Go back to
Chlorine Binding Sites List in 5os5
Chlorine binding site 2 out
of 3 in the Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment within 5.0Å range:
|
Chlorine binding site 3 out of 3 in 5os5
Go back to
Chlorine Binding Sites List in 5os5
Chlorine binding site 3 out
of 3 in the Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of Aurora-A Kinase in Complex with An Allosterically Binding Fragment within 5.0Å range:
|
Reference:
P.J.Mcintyre,
P.M.Collins,
L.Vrzal,
K.Birchall,
L.H.Arnold,
C.Mpamhanga,
P.J.Coombs,
S.G.Burgess,
M.W.Richards,
A.Winter,
V.Veverka,
F.V.Delft,
A.Merritt,
R.Bayliss.
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. Acs Chem. Biol. V. 12 2906 2017.
ISSN: ESSN 1554-8937
PubMed: 29045126
DOI: 10.1021/ACSCHEMBIO.7B00537
Page generated: Sat Jul 12 06:56:06 2025
ISSN: ESSN 1554-8937
PubMed: 29045126
DOI: 10.1021/ACSCHEMBIO.7B00537
Last articles
Mg in 4E8GMg in 4E84
Mg in 4E89
Mg in 4DV7
Mg in 4E7Z
Mg in 4E6M
Mg in 4E7S
Mg in 4E7P
Mg in 4E7O
Mg in 4E5T
