Atomistry » Chlorine » PDB 5os7-5oum » 5osc
Atomistry »
  Chlorine »
    PDB 5os7-5oum »
      5osc »

Chlorine in PDB 5osc: Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5

Protein crystallography data

The structure of Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5, PDB code: 5osc was solved by D.C.Laverty, M.G.Gold, T.G.Smart, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.92 / 3.10
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 183.310, 133.180, 161.860, 90.00, 102.71, 90.00
R / Rfree (%) 21.1 / 24.6

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5 (pdb code 5osc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5, PDB code: 5osc:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 5osc

Go back to Chlorine Binding Sites List in 5osc
Chlorine binding site 1 out of 5 in the Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl502

b:89.8
occ:1.00
 N A:PHE77 3.3 76.5 1.0
N A:ARG84 3.5 60.4 1.0
CD2 A:PHE77 3.5 94.0 1.0
NH1 A:ARG84 3.5 0.9 1.0
CB A:PHE77 3.6 87.9 1.0
CG A:ARG84 3.8 85.6 1.0
CA A:PHE77 4.0 78.9 1.0
CG A:PHE77 4.0 93.5 1.0
CA A:ALA83 4.0 89.2 1.0
CB A:ARG84 4.0 74.2 1.0
CG1 A:VAL80 4.2 81.4 1.0
CD A:ARG84 4.2 92.3 1.0
O A:PHE77 4.2 73.3 1.0
C A:ARG76 4.3 83.2 1.0
CA A:ARG76 4.3 77.5 1.0
C A:ALA83 4.3 85.7 1.0
CA A:ARG84 4.4 73.3 1.0
C A:PHE77 4.6 77.2 1.0
CE2 A:PHE77 4.6 98.0 1.0
CZ A:ARG84 4.6 0.9 1.0
CB A:ALA83 4.7 0.1 1.0
CB A:ARG76 4.7 69.7 1.0
O A:ASN82 4.8 99.7 1.0
CG A:ARG76 4.8 92.6 1.0
NE A:ARG84 4.9 95.5 1.0

Chlorine binding site 2 out of 5 in 5osc

Go back to Chlorine Binding Sites List in 5osc
Chlorine binding site 2 out of 5 in the Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl503

b:85.0
occ:1.00
 N B:ARG84 3.4 71.0 1.0
NH1 B:ARG84 3.4 86.3 1.0
N B:PHE77 3.6 93.5 1.0
CD2 B:PHE77 3.6 95.0 1.0
CG B:ARG84 3.6 68.5 1.0
CB B:PHE77 3.9 68.2 1.0
CB B:ARG84 3.9 75.7 1.0
CA B:ALA83 4.0 82.2 1.0
CD B:ARG84 4.0 92.7 1.0
C B:ALA83 4.2 82.8 1.0
CG B:PHE77 4.3 79.2 1.0
CA B:ARG84 4.3 84.8 1.0
CA B:PHE77 4.3 81.0 1.0
CZ B:ARG84 4.4 98.5 1.0
CA B:ARG76 4.4 83.6 1.0
CB B:ALA83 4.5 0.4 1.0
C B:ARG76 4.5 93.4 1.0
O B:PHE77 4.5 88.5 1.0
CE2 B:PHE77 4.7 91.3 1.0
NE B:ARG84 4.7 0.9 1.0
CG B:ARG76 4.8 78.8 1.0
CB B:ARG76 4.9 71.0 1.0
C B:PHE77 4.9 76.5 1.0
O B:ASN82 4.9 0.3 1.0

Chlorine binding site 3 out of 5 in 5osc

Go back to Chlorine Binding Sites List in 5osc
Chlorine binding site 3 out of 5 in the Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl502

b:97.3
occ:1.00
 N C:PHE77 3.3 96.4 1.0
NH1 C:ARG84 3.6 1.0 1.0
N C:ARG84 3.6 60.1 1.0
CB C:PHE77 3.9 80.5 1.0
CA C:ALA83 3.9 77.9 1.0
CD2 C:PHE77 4.1 91.0 1.0
O C:PHE77 4.1 76.4 1.0
CA C:PHE77 4.1 87.5 1.0
CG C:ARG84 4.1 94.4 1.0
CA C:ARG76 4.1 75.3 1.0
C C:ARG76 4.2 95.4 1.0
C C:ALA83 4.3 78.1 1.0
CG C:ARG76 4.4 87.9 1.0
CB C:ARG84 4.4 88.0 1.0
CB C:ALA83 4.4 0.6 1.0
CB C:ARG76 4.4 69.9 1.0
CG C:PHE77 4.5 85.8 1.0
CD C:ARG84 4.5 0.3 1.0
C C:PHE77 4.6 83.6 1.0
CA C:ARG84 4.7 88.8 1.0
CZ C:ARG84 4.8 0.8 1.0
O C:ASN82 4.9 0.0 1.0

Chlorine binding site 4 out of 5 in 5osc

Go back to Chlorine Binding Sites List in 5osc
Chlorine binding site 4 out of 5 in the Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl503

b:85.4
occ:1.00
 NH1 D:ARG84 3.3 95.2 1.0
N D:ARG84 3.4 81.1 1.0
N D:PHE77 3.5 91.5 1.0
CG D:ARG84 3.5 74.4 1.0
CD2 D:PHE77 3.5 97.8 1.0
CB D:ARG84 3.7 73.0 1.0
CD D:ARG84 3.8 92.6 1.0
CB D:PHE77 3.9 83.4 1.0
CG D:PHE77 4.2 89.7 1.0
CA D:ALA83 4.2 96.6 1.0
CA D:ARG84 4.2 70.8 1.0
CA D:PHE77 4.2 85.1 1.0
C D:ALA83 4.3 95.3 1.0
CZ D:ARG84 4.3 93.8 1.0
CA D:ARG76 4.3 91.6 1.0
C D:ARG76 4.4 92.0 1.0
CE2 D:PHE77 4.5 88.9 1.0
NE D:ARG84 4.5 93.8 1.0
CG1 D:VAL80 4.5 87.8 1.0
O D:PHE77 4.6 87.4 1.0
CB D:ALA83 4.8 0.2 1.0
CG D:ARG76 4.8 0.3 1.0
CB D:ARG76 4.8 93.6 1.0
C D:PHE77 4.9 81.4 1.0
O D:ASN82 5.0 0.0 1.0
O D:ILE75 5.0 0.1 1.0

Chlorine binding site 5 out of 5 in 5osc

Go back to Chlorine Binding Sites List in 5osc
Chlorine binding site 5 out of 5 in the Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Glic-Gabaar ALPHA1 Chimera Crystallized in Complex with Pregnenolone Sulfate at pH 4.5 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl503

b:97.7
occ:1.00
 NH1 E:ARG84 3.4 0.4 1.0
N E:PHE77 3.4 0.2 1.0
N E:ARG84 3.5 66.2 1.0
CG E:ARG84 3.9 80.5 1.0
CD2 E:PHE77 3.9 0.1 1.0
CA E:ALA83 3.9 75.8 1.0
CB E:PHE77 4.0 82.2 1.0
CA E:ARG76 4.2 71.9 1.0
CB E:ARG84 4.2 66.9 1.0
C E:ALA83 4.3 85.9 1.0
CA E:PHE77 4.3 80.0 1.0
CD E:ARG84 4.3 84.6 1.0
C E:ARG76 4.3 99.7 1.0
CB E:ALA83 4.4 0.1 1.0
O E:PHE77 4.5 76.1 1.0
CG E:PHE77 4.5 90.9 1.0
CZ E:ARG84 4.5 99.6 1.0
CA E:ARG84 4.5 82.2 1.0
CG1 E:VAL80 4.5 64.7 1.0
CG E:ARG76 4.6 88.3 1.0
CB E:ARG76 4.7 65.0 1.0
NE E:ARG84 4.8 0.1 1.0
C E:PHE77 4.8 80.1 1.0
CE2 E:PHE77 5.0 0.1 1.0
O E:ILE75 5.0 95.6 1.0

Reference:

D.Laverty, P.Thomas, M.Field, O.J.Andersen, M.G.Gold, P.C.Biggin, M.Gielen, T.G.Smart. Crystal Structures of A Gabaa-Receptor Chimera Reveal New Endogenous Neurosteroid-Binding Sites. Nat. Struct. Mol. Biol. V. 24 977 2017.
ISSN: ESSN 1545-9985
PubMed: 28967882
DOI: 10.1038/NSMB.3477
Page generated: Sat Jul 12 06:57:01 2025

Last articles

Mg in 7BOE
Mg in 7BGI
Mg in 7BLX
Mg in 7BLZ
Mg in 7BOD
Mg in 7BNR
Mg in 7BNK
Mg in 7BMC
Mg in 7BM9
Mg in 7BM8
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy