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Chlorine in PDB 5p8x: Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A

Enzymatic activity of Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A

All present enzymatic activity of Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A:
2.1.1.6;

Protein crystallography data

The structure of Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A, PDB code: 5p8x was solved by A.Ehler, C.Lerner, M.G.Rudolph, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.28 / 1.31
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 50.178, 54.172, 80.557, 90.00, 90.00, 90.00
R / Rfree (%) 13 / 15.6

Other elements in 5p8x:

The structure of Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A (pdb code 5p8x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A, PDB code: 5p8x:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 5p8x

Go back to Chlorine Binding Sites List in 5p8x
Chlorine binding site 1 out of 2 in the Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl302

b:16.3
occ:1.00
O A:HOH460 3.2 14.3 1.0
O A:HOH418 3.2 20.6 1.0
OG A:SER72 3.2 23.2 0.5
N A:VAL42 3.3 12.1 1.0
N A:SER72 3.4 12.8 1.0
OG A:SER72 3.5 16.6 0.5
CA A:ASN41 3.6 12.0 1.0
CB A:SER72 3.6 13.7 0.5
CB A:SER72 3.7 15.4 0.5
CB A:TYR71 3.7 12.9 1.0
CG2 A:VAL42 3.9 13.2 0.5
C A:ASN41 3.9 11.5 1.0
OD2 A:ASP141 4.0 12.4 1.0
CA A:SER72 4.1 13.1 0.5
CA A:SER72 4.1 13.7 0.5
CB A:ASN41 4.1 13.4 1.0
CD2 A:TYR71 4.1 12.4 1.0
C A:TYR71 4.2 12.3 1.0
N A:TYR71 4.2 12.6 1.0
CA A:TYR71 4.2 12.3 1.0
O A:HOH429 4.3 12.0 1.0
O A:HOH474 4.3 19.0 1.0
CB A:VAL42 4.3 12.3 0.5
O A:ALA67 4.3 14.8 1.0
CG A:TYR71 4.4 11.6 1.0
ND2 A:ASN41 4.4 12.8 1.0
O A:MET40 4.4 13.5 1.0
CA A:VAL42 4.4 12.3 0.5
CB A:VAL42 4.5 13.6 0.5
CA A:VAL42 4.5 12.4 0.5
CG1 A:VAL42 4.6 15.4 0.5
N A:ASN41 4.7 12.0 1.0
CG A:ASN41 4.8 13.1 1.0
CB A:TYR68 5.0 13.9 1.0

Chlorine binding site 2 out of 2 in 5p8x

Go back to Chlorine Binding Sites List in 5p8x
Chlorine binding site 2 out of 2 in the Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Humanized Rat Catechol O-Methyltransferase in Complex with N-[2-[5- (1H-Benzimidazol-5-Yl)-4H-1,2,4-Triazol-3-Yl]Ethyl]-5-(4- Fluorophenyl)-2,3-Dihydroxybenzamide at 1.31A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl303

b:19.9
occ:1.00
O A:HOH534 2.9 30.6 1.0
O A:HOH585 3.2 33.8 1.0
O A:HOH516 3.3 21.3 1.0
N A:TYR200 3.3 12.7 1.0
N A:ASP44 3.4 15.2 1.0
N A:ALA45 3.5 14.2 1.0
O A:HOH496 3.6 16.0 1.0
CA A:GLU199 4.0 11.8 1.0
CB A:ALA45 4.0 16.8 1.0
CA A:TYR200 4.1 13.7 1.0
CD1 A:TYR200 4.1 15.8 1.0
C A:GLY43 4.1 13.3 1.0
CA A:GLY43 4.1 13.0 1.0
C A:GLU199 4.2 11.4 1.0
CA A:ASP44 4.2 16.3 1.0
C A:ASP44 4.3 14.2 1.0
CE1 A:TYR200 4.4 15.5 1.0
CB A:ASP44 4.4 18.6 1.0
CA A:ALA45 4.4 14.2 1.0
O A:HOH522 4.4 40.9 1.0
CG A:TYR200 4.7 14.5 1.0
CB A:GLU199 4.7 11.4 1.0
O A:LEU198 4.8 11.4 1.0
O A:HOH512 4.9 32.7 1.0
N A:GLU199 5.0 11.7 1.0

Reference:

C.Lerner, M.G.Rudolph. Crystal Structure of A Comt Complex To Be Published.
Page generated: Fri Jul 26 14:59:51 2024

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