Atomistry » Chlorine » PDB 5pb5-5qa5 » 5pzv
Atomistry »
  Chlorine »
    PDB 5pb5-5qa5 »
      5pzv »

Chlorine in PDB 5pzv: Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea

Enzymatic activity of Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea

All present enzymatic activity of Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea:
3.1.3.11;

Protein crystallography data

The structure of Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea, PDB code: 5pzv was solved by A.Ruf, C.Joseph, A.Alker, D.Banner, T.Tetaz, J.Benz, B.Kuhn, M.G.Rudolph, H.Yang, C.Shao, S.K.Burley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.67 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 67.618, 83.409, 277.065, 90.00, 90.00, 90.00
R / Rfree (%) 19.1 / 23.9

Other elements in 5pzv:

The structure of Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea also contains other interesting chemical elements:

Bromine (Br) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea (pdb code 5pzv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea, PDB code: 5pzv:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 5pzv

Go back to Chlorine Binding Sites List in 5pzv
Chlorine binding site 1 out of 4 in the Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:57.3
occ:1.00
 CL21 A:94G401 0.0 57.3 1.0
C16 A:94G401 1.8 44.3 1.0
C19 A:94G401 2.7 39.6 1.0
C18 A:94G401 2.7 34.9 1.0
SD A:MET177 3.5 50.3 1.0
CE A:MET177 3.6 50.5 1.0
CB A:GLU20 3.6 50.7 1.0
O A:HOH676 3.8 36.4 1.0
O A:HOH602 3.8 34.1 1.0
C12 A:94G401 4.0 36.5 1.0
C13 A:94G401 4.0 34.7 1.0
C A:GLU20 4.3 32.0 1.0
O A:GLU20 4.4 29.7 1.0
N A:GLY21 4.5 27.8 1.0
C6 A:94G401 4.5 35.2 1.0
CG A:GLU20 4.6 61.9 1.0
CA A:GLU20 4.6 42.4 1.0
CG A:MET177 4.7 44.3 1.0
CB A:MET177 4.7 32.7 1.0
OE1 A:GLU20 4.9 74.9 1.0
CA A:GLY21 4.9 24.8 1.0

Chlorine binding site 2 out of 4 in 5pzv

Go back to Chlorine Binding Sites List in 5pzv
Chlorine binding site 2 out of 4 in the Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl401

b:71.1
occ:1.00
 CL21 B:94G401 0.0 71.1 1.0
C16 B:94G401 1.7 52.6 1.0
C18 B:94G401 2.7 43.0 1.0
C19 B:94G401 2.7 41.4 1.0
O B:HOH688 3.4 41.9 1.0
CB B:GLU20 3.4 28.4 1.0
SD B:MET177 3.8 38.2 1.0
CE B:MET177 3.9 38.5 1.0
C13 B:94G401 4.0 42.4 1.0
C12 B:94G401 4.0 38.3 1.0
O B:HOH559 4.1 38.2 1.0
C B:GLU20 4.1 35.5 1.0
O B:GLU20 4.3 32.6 1.0
CG B:GLU20 4.4 44.0 1.0
CA B:GLU20 4.4 35.0 1.0
N B:GLY21 4.4 23.5 1.0
OE1 B:GLU20 4.5 57.4 1.0
C6 B:94G401 4.5 39.5 1.0
CD2 B:LEU30 4.8 17.2 1.0
CA B:GLY21 4.9 24.9 1.0
CD B:GLU20 4.9 53.3 1.0

Chlorine binding site 3 out of 4 in 5pzv

Go back to Chlorine Binding Sites List in 5pzv
Chlorine binding site 3 out of 4 in the Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl401

b:59.6
occ:1.00
 CL21 C:94G401 0.0 59.6 1.0
C16 C:94G401 1.7 35.8 1.0
C19 C:94G401 2.7 33.0 1.0
C18 C:94G401 2.7 24.8 1.0
CB C:GLU20 3.4 34.5 1.0
O C:HOH656 3.6 47.4 1.0
O C:HOH685 3.6 37.1 1.0
O C:HOH749 3.6 41.6 1.0
SD C:MET177 4.0 33.4 1.0
CE C:MET177 4.0 40.4 1.0
C12 C:94G401 4.0 21.7 1.0
C13 C:94G401 4.0 32.0 1.0
O C:GLU20 4.0 34.7 1.0
C C:GLU20 4.1 31.7 1.0
OE1 C:GLU20 4.3 56.8 1.0
CG C:GLU20 4.3 45.0 1.0
CA C:GLU20 4.4 30.8 1.0
N C:GLY21 4.4 28.1 1.0
C6 C:94G401 4.5 22.5 1.0
CD C:GLU20 4.8 52.2 1.0
CA C:GLY21 4.9 30.6 1.0

Chlorine binding site 4 out of 4 in 5pzv

Go back to Chlorine Binding Sites List in 5pzv
Chlorine binding site 4 out of 4 in the Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl401

b:66.5
occ:1.00
 CL21 D:94G401 0.0 66.5 1.0
C16 D:94G401 1.7 52.5 1.0
C18 D:94G401 2.7 41.7 1.0
C19 D:94G401 2.7 45.0 1.0
SD D:MET177 3.5 36.3 1.0
CB D:GLU20 3.9 45.5 1.0
CE D:MET177 4.0 36.2 1.0
C13 D:94G401 4.0 30.3 1.0
C12 D:94G401 4.0 41.7 1.0
O D:HOH504 4.2 48.9 1.0
C6 D:94G401 4.5 35.9 1.0
C D:GLU20 4.5 32.8 1.0
O D:GLU20 4.5 33.0 1.0
OE1 D:GLU20 4.6 70.5 1.0
CD2 D:LEU30 4.7 16.6 1.0
CG D:GLU20 4.8 52.5 1.0
CG D:MET177 4.8 32.1 1.0
CB D:MET177 4.8 21.3 1.0
N D:GLY21 4.8 34.1 1.0
CA D:GLU20 4.9 38.9 1.0

Reference:

A.Ruf, C.Joseph, A.Alker, D.Banner, T.Tetaz, J.Benz, B.Kuhn, M.G.Rudolph. Human Liver Fructose-1,6-Bisphosphatase 1 (Fructose 1,6-Bisphosphate 1-Phosphatase, E.C.3.1.3.11) Complexed with the Allosteric Inhibitor 1-(4-Bromopyridin-2-Yl)-3-(4-Chlorophenyl)Sulfonylurea To Be Published.
Page generated: Fri Jul 26 15:11:48 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy