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Chlorine in PDB 5sb8: Tubulin-Maytansinoid-3-Complex

Protein crystallography data

The structure of Tubulin-Maytansinoid-3-Complex, PDB code: 5sb8 was solved by P.Marzullo, Z.Boiarska, H.Perez-Pena, A.-C.Abel, B.Alvarez-Bernad, D.Lucena-Agell, F.Vasile, M.Sironi, M.O.Steinmetz, A.E.Prota, J.F.Diaz, S.Pieraccini, D.Passarella, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.66 / 2.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 104.664, 157.491, 181.511, 90, 90, 90
R / Rfree (%) 19.3 / 23

Other elements in 5sb8:

The structure of Tubulin-Maytansinoid-3-Complex also contains other interesting chemical elements:

Magnesium (Mg) 5 atoms
Calcium (Ca) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Tubulin-Maytansinoid-3-Complex (pdb code 5sb8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Tubulin-Maytansinoid-3-Complex, PDB code: 5sb8:

Chlorine binding site 1 out of 1 in 5sb8

Go back to Chlorine Binding Sites List in 5sb8
Chlorine binding site 1 out of 1 in the Tubulin-Maytansinoid-3-Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Tubulin-Maytansinoid-3-Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl503

b:107.1
occ:1.00
CL33 D:5IS503 0.0 107.1 1.0
C6 D:5IS503 1.8 94.8 1.0
C1 D:5IS503 2.7 96.1 1.0
C5 D:5IS503 2.8 96.9 1.0
O34 D:5IS503 2.9 97.9 1.0
N31 D:5IS503 3.2 99.9 1.0
C36 D:5IS503 3.6 85.4 1.0
C35 D:5IS503 3.8 86.9 1.0
CZ D:PHE404 3.8 101.1 1.0
C28 D:5IS503 3.8 91.2 1.0
C2 D:5IS503 4.1 85.4 1.0
C4 D:5IS503 4.1 91.6 1.0
C27 D:5IS503 4.1 80.1 1.0
CG1 D:VAL181 4.1 94.3 1.0
CE1 D:PHE404 4.5 107.8 1.0
C3 D:5IS503 4.6 87.8 1.0
CE2 D:PHE404 4.7 100.8 1.0
O32 D:5IS503 4.7 92.0 1.0
CB D:VAL181 4.7 96.0 1.0

Reference:

P.Marzullo, Z.Boiarska, H.Perez-Pena, A.C.Abel, B.Alvarez-Bernad, D.Lucena-Agell, F.Vasile, M.Sironi, K.H.Altmann, A.E.Prota, J.F.Diaz, S.Pieraccini, D.Passarella. Maytansinol Derivatives: Side Reactions As A Chance For New Tubulin Binders. Chemistry 2021.
ISSN: ISSN 0947-6539
PubMed: 34788896
DOI: 10.1002/CHEM.202103520
Page generated: Sat Jul 12 08:20:17 2025

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