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Chlorine in PDB 5sd8: Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture)

Enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture)

All present enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture):
1.5.1.3;

Protein crystallography data

The structure of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture), PDB code: 5sd8 was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.86 / 2.05
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 73.85, 73.85, 143.97, 90, 90, 90
R / Rfree (%) 16.2 / 18

Other elements in 5sd8:

The structure of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture) also contains other interesting chemical elements:

Fluorine (F) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture) (pdb code 5sd8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture), PDB code: 5sd8:

Chlorine binding site 1 out of 1 in 5sd8

Go back to Chlorine Binding Sites List in 5sd8
Chlorine binding site 1 out of 1 in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl206

b:41.4
occ:1.00
 NH2 A:ARG138 3.1 25.8 1.0
O A:HOH348 3.2 39.7 1.0
N A:ILE152 3.3 31.4 1.0
NH1 A:ARG138 3.6 29.8 1.0
CE A:MET15 3.6 46.6 1.0
CZ A:ARG138 3.8 34.8 1.0
CA A:GLU151 3.9 45.1 1.0
CG1 A:ILE152 3.9 28.2 1.0
CB A:ILE152 4.0 31.5 1.0
CG A:GLU151 4.0 58.6 1.0
C A:GLU151 4.1 35.2 1.0
CA A:ILE152 4.3 37.9 1.0
CD1 A:ILE152 4.3 25.4 1.0
CB A:GLU151 4.4 51.6 1.0
SD A:MET15 4.4 53.8 1.0
O A:PRO150 4.7 33.3 1.0
O A:ILE152 4.9 38.7 1.0
CE2 A:PHE149 5.0 32.1 1.0

Reference:

S.J.Mayclin, J.W.Fairman, D.M.Dranow, D.G.Conrady, D.Fox Iii, C.M.Lukacs, D.D.Lorimer, P.S.Horanyi, T.E.Edwards, J.Abendroth. Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-1190 (Racemic Mixture) To Be Published.
Page generated: Fri Jul 26 16:42:39 2024

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