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Chlorine in PDB 5sk1: Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide
Enzymatic activity of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide
All present enzymatic activity of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide:
3.1.4.17;
3.1.4.17;
Protein crystallography data
The structure of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide, PDB code: 5sk1
was solved by
C.Joseph,
J.Benz,
A.Flohr,
J.Peters,
M.G.Rudolph,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 41.37 / 2.30 |
| Space group | H 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 134.851, 134.851, 234.435, 90, 90, 120 |
| R / Rfree (%) | 18.5 / 23.8 |
Other elements in 5sk1:
The structure of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide also contains other interesting chemical elements:
| Magnesium | (Mg) | 4 atoms |
| Zinc | (Zn) | 4 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide
(pdb code 5sk1). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide, PDB code: 5sk1:
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide, PDB code: 5sk1:
Chlorine binding site 1 out of 1 in 5sk1
Go back to
Chlorine Binding Sites List in 5sk1
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,2- Dimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyrimidin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
|
Reference:
A.Flohr,
D.Schlatter,
B.Kuhn,
M.G.Rudolph.
Crystal Structure of A Human Phosphodiesterase 10 Complex To Be Published.
Page generated: Sat Jul 12 08:33:59 2025
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