Chlorine in PDB 5sxu: X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State

The structure of X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State, PDB code: 5sxu was solved by Q.Chen, M.Kinde, A.Cohen, Y.Xu, P.Tang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.93 / 3.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	105.903, 266.791, 111.109, 90.00, 107.13, 90.00
R / Rfree (%)	20 / 23.9

The structure of X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State also contains other interesting chemical elements:

Bromine

(Br)

32 atoms

The binding sites of Chlorine atom in the X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State (pdb code 5sxu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State, PDB code: 5sxu:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl406 b:0.6 occ:1.00 NH2 I:ARG163 3.5 0.5 1.0 CE1 C:HIS177 3.7 0.4 1.0 NE2 C:HIS177 4.1 0.1 1.0 CZ I:ARG163 4.5 0.8 1.0 NH1 I:ARG163 4.8 0.4 1.0 ND1 C:HIS177 4.9 0.9 1.0

Chlorine binding site 2 out of 2 in the X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of X-Ray Structure of 2-Bromoethanol Bound to A Pentameric Ligand Gated Ion Channel (Elic) in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ J:Cl506 b:0.0 occ:1.00 NZ J:LYS90 3.2 0.0 1.0 CE J:LYS90 4.1 0.9 1.0

Q.Chen, M.M.Wells, T.S.Tillman, M.N.Kinde, A.Cohen, Y.Xu, P.Tang. Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel Elic. Structure V. 25 180 2017.
ISSN: ISSN 1878-4186
PubMed: 27916519
DOI: 10.1016/J.STR.2016.11.007