Chlorine in PDB 5t1a: Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

Enzymatic activity of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

All present enzymatic activity of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists:
3.2.1.17;

Protein crystallography data

The structure of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists, PDB code: 5t1a was solved by Y.Zheng, L.Qin, N.V.Ortiz Zacarias, H.De Vries, G.W.Han, M.Gustavsson, M.Dabros, C.Zhao, R.J.Cherney, P.Carter, D.Stamos, R.Abagyan, V.Cherezov, R.C.Stevens, A.P.Ijzerman, L.H.Heitman, A.Tebben, I.Kufareva, T.M.Handel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	24.32 / 2.81
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	59.230, 64.690, 169.980, 90.00, 90.00, 90.00
*R / R_free (%)*	23.4 / 27.4

Other elements in 5t1a:

The structure of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Zinc	(Zn)	1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists (pdb code 5t1a). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists, PDB code: 5t1a:

Chlorine binding site 1 out of 1 in 5t1a

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Chlorine Binding Sites List in 5t1a

Chlorine binding site 1 out of 1 in the Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl1202 b:57.4 occ:1.00	CL	A:VT51202	0.0	57.4	1.0
	C15	A:VT51202	1.8	23.6	1.0
	C14	A:VT51202	2.7	24.5	1.0
	C16	A:VT51202	2.8	23.9	1.0
	CG1	A:VAL63	3.6	24.6	1.0
	CD1	A:PHE312	3.7	32.5	1.0
	CE1	A:PHE312	3.8	32.3	1.0
	CD2	A:LEU67	4.0	25.2	1.0
	C13	A:VT51202	4.0	25.1	1.0
	CG	A:LEU67	4.1	29.5	1.0
	C17	A:VT51202	4.1	25.1	1.0
	CD1	A:LEU81	4.3	24.8	1.0
	CD1	A:LEU67	4.3	29.7	1.0
	CE2	A:TYR305	4.4	24.6	1.0
	O	A:VAL63	4.4	44.4	1.0
	CD2	A:TYR305	4.4	24.5	1.0
	CB	A:VAL63	4.4	25.5	1.0
	CG2	A:VAL63	4.5	25.5	1.0
	C12	A:VT51202	4.6	24.9	1.0
	CA	A:VAL63	4.6	42.5	1.0
	CB	A:LEU81	4.8	22.1	1.0
	CG	A:PHE312	4.9	33.0	1.0
	C	A:VAL63	4.9	43.0	1.0

Reference:

Y.Zheng, L.Qin, N.V.Zacarias, H.De Vries, G.W.Han, M.Gustavsson, M.Dabros, C.Zhao, R.J.Cherney, P.Carter, D.Stamos, R.Abagyan, V.Cherezov, R.C.Stevens, A.P.Ijzerman, L.H.Heitman, A.Tebben, I.Kufareva, T.M.Handel. Structure of Cc Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists. Nature V. 540 458 2016.
ISSN: ESSN 1476-4687
PubMed: 27926736
DOI: 10.1038/NATURE20605

Page generated: Sat Jul 12 08:46:23 2025

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